Download all files (9.77MB)

コレクション

引用

説明:

The objective of the study is to investigate the safety, feasibility, and degradation profile of a novel Mg alloy-based bioresorbable coronary scaffold (JFK-PRODUCT BRS) with thin struts (110 μm). Fourteen healthy pigs received 17 JFK-PRODUCT BRSs in the coronary arteries and were sacrificed at 1, 6, 12, 18, and 26 months after implantation. Angiography, optical coherence tomography, microfocus X-ray computed tomography (μCT), scanning electron microscopy with energy-dispersive X-ray spectrometry (SEM–EDX), and histopathological evaluation were performed. The JFK-PRODUCT had a median percent late recoil of 11.28% at 1 month. The μCT observation confirmed that scaffold discontinuity reached 64.8% at 12 months with increased scaffold inner area thereafter, suggesting artery positive remodeling. The inflammation was mild, peaked at 18 months, and decreased thereafter. The SEM–EDX analysis demonstrated gradual degradation of the scaffold with formation of inorganic deposits, presumed to be calcium phosphates. It also revealed the disappearance of calcium phosphates at 26 months, achieving almost complete replacement of the scaffold by biocomponents.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

  This article is licensed under a Creative Commons Attribution
  4.0 International License, which permits use, sharing, adaptation,
  distribution and reproduction in any medium or format, as long
  as you give appropriate credit to the original author(s) and the source,
  provide a link to the Creative Commons licence, and indicate if changes
  were made. The images or other third party material in this article are
  included in the article’s Creative Commons licence, unless indicated
  otherwise in a credit line to the material. If material is not included in
  the article’s Creative Commons licence and your intended use is not
  permitted by statutory regulation or exceeds the permitted use, you will
  need to obtain permission directly from the copyright holder. To view a
  copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

キーワード: Percutaneous coronary intervention, Bioabsorbable magnesium scaffolds, Preclinical study, Elemental mapping, Controlled degradation profile

刊行年月日: 2024-07-22

出版者: Springer Science and Business Media LLC

掲載誌:

• Cardiovascular Intervention and Therapeutics (ISSN: 18684300) vol. 39 issue. 4 p. 428-437

研究助成金:

• AMED 18pc0101027h0001 (CiCLE)

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1007/s12928-024-01023-3

関連資料:

その他の識別子:

連絡先:

更新時刻: 2024-10-18 16:30:14 +0900

MDRでの公開時刻: 2024-10-18 16:30:15 +0900