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Carbonate apatite (CAp) and hydroxyapatite (HAp) coatings have been developed as bioabsorbable and non-absorbable corrosion suppression coatings, respectively, for biodegradable Mg alloys. In this study, CAp and HAp coatings were formed on Mg-0.8mass% Ca (MgCa) alloy plates and screws and implanted in rabbit femurs with uncoated devices for 2 and 6 months. Cross section of the retrieved devices was observed using scanning electron microscope to observe the details. The CAp and HAp coatings suppressed apparent corrosion of MgCa devices for 2 months. The CAp coating suppressed subsequent corrosion to show only several micro corrosion pits. The cross-sectional reduction of the CAp-coated plates and screws at 6 months was about 20% and 50% of that of the uncoated devices, respectively. The corrosion of the HAp-coated devices progressed locally to show millimeter-sized pits at 6 months, and their cross-sectional reduction was around 50% of that of the uncoated devices. The CAp coating began to disintegrate between 2 and 6 months preferentially in area with new bone formation, while the HAp coating almost remained the original shape. It was shown that the CAp coating can suppress the corrosion of MgCa and be absorbed by new bone.

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• In Copyright
  

  This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s44174-024-00217-w.

Keyword: Bioabsorbable carbonate apatite coating, biodegradable magnesium alloy, in vivo, biomaterials

Date published: 2024-08-02

Publisher: Springer Science and Business Media LLC

Journal:

• Biomedical Materials & Devices (ISSN: 27314812) vol. 3 issue. 2 p. 1183-1199

Funding:

• Japan Society for the Promotion of Science 20K10012
• Japan Society for the Promotion of Science 22H01798

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5674

First published URL: https://doi.org/10.1007/s44174-024-00217-w

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Updated at: 2025-08-27 12:30:23 +0900

Published on MDR: 2025-08-27 08:19:16 +0900