Download file (8.47MB)
Download as zip (8.38MB)

コレクション

引用

説明:

Carbonate apatite (CAp) and hydroxyapatite (HAp) coatings have been developed as bioabsorbable and non-absorbable corrosion suppression coatings, respectively, for biodegradable Mg alloys. In this study, CAp and HAp coatings were formed on Mg-0.8mass% Ca (MgCa) alloy plates and screws and implanted in rabbit femurs with uncoated devices for 2 and 6 months. Cross section of the retrieved devices was observed using scanning electron microscope to observe the details. The CAp and HAp coatings suppressed apparent corrosion of MgCa devices for 2 months. The CAp coating suppressed subsequent corrosion to show only several micro corrosion pits. The cross-sectional reduction of the CAp-coated plates and screws at 6 months was about 20% and 50% of that of the uncoated devices, respectively. The corrosion of the HAp-coated devices progressed locally to show millimeter-sized pits at 6 months, and their cross-sectional reduction was around 50% of that of the uncoated devices. The CAp coating began to disintegrate between 2 and 6 months preferentially in area with new bone formation, while the HAp coating almost remained the original shape. It was shown that the CAp coating can suppress the corrosion of MgCa and be absorbed by new bone.

権利情報:

• In Copyright
  

  This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s44174-024-00217-w.

キーワード: Bioabsorbable carbonate apatite coating, biodegradable magnesium alloy, in vivo, biomaterials

刊行年月日: 2024-08-02

出版者: Springer Science and Business Media LLC

掲載誌:

• Biomedical Materials & Devices (ISSN: 27314812) vol. 3 issue. 2 p. 1183-1199

研究助成金:

• Japan Society for the Promotion of Science 20K10012
• Japan Society for the Promotion of Science 22H01798

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5674

公開URL: https://doi.org/10.1007/s44174-024-00217-w

関連資料:

その他の識別子:

連絡先:

更新時刻: 2025-08-27 12:30:23 +0900

MDRでの公開時刻: 2025-08-27 08:19:16 +0900