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Description:

Conductive 2D membranes are attractive for nanopore sensing, as they simultaneously offer spatial resolution for interrogating a few nucleotides and the potential to integrate with wafer-scale circuits for low-noise measurements and multiplexing. Vertical 2D junctions exhibit an atomically sharp hetero-interface without a depletion region, opening new possibilities for biosensing. Here we present a novel nanopore sensing architecture in a dielectric-encapsulated vertical 2D heterojunction diode of p-type WSe₂ on n-type MoS₂. The encapsulation allows robust operation while preserving spatial resolution down to a few nucleotides. We demonstrate that ionic potential modulates the heterojunction transport and, conversely, that heterojunction potential modulates ionic transport. Additionally, we achieve concurrent electrical and ionic sensing of DNA translocation, alongside electrical control of translocation speed. These findings establish a new paradigm for electrical DNA sensing and sequencing using solid-state nanopores.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: DNA translocation, nanopore
, van der Waals heterojunction


Date published: 2025-05-06

Publisher: Proceedings of the National Academy of Sciences

Journal:

• Proceedings of the National Academy of Sciences (ISSN: 00278424) vol. 122 issue. 18 e2422135122

Funding:

• Taiwan Semiconductor Manufacturing Company 089401
• Taiwan Semiconductor Manufacturing Company 089401
• HHS | NIH | National Human Genome Research Institute R21HG010701
• HHS | NIH | National Human Genome Research Institute R21HG010701
• NSF | MPS | Division of Materials Research 2309037
• MEXT | Japan Society for the Promotion of Science 21H05233
• MEXT | Japan Society for the Promotion of Science 21H05233
• MEXT | Japan Society for the Promotion of Science 23H02052
• MEXT | Japan Society for the Promotion of Science 23H02052

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1073/pnas.2422135122

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Updated at: 2026-02-17 08:30:24 +0900

Published on MDR: 2026-02-16 18:00:50 +0900