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説明:

Conductive 2D membranes are attractive for nanopore sensing, as they simultaneously offer spatial resolution for interrogating a few nucleotides and the potential to integrate with wafer-scale circuits for low-noise measurements and multiplexing. Vertical 2D junctions exhibit an atomically sharp hetero-interface without a depletion region, opening new possibilities for biosensing. Here we present a novel nanopore sensing architecture in a dielectric-encapsulated vertical 2D heterojunction diode of p-type WSe₂ on n-type MoS₂. The encapsulation allows robust operation while preserving spatial resolution down to a few nucleotides. We demonstrate that ionic potential modulates the heterojunction transport and, conversely, that heterojunction potential modulates ionic transport. Additionally, we achieve concurrent electrical and ionic sensing of DNA translocation, alongside electrical control of translocation speed. These findings establish a new paradigm for electrical DNA sensing and sequencing using solid-state nanopores.

権利情報:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

キーワード: DNA translocation, nanopore
, van der Waals heterojunction


刊行年月日: 2025-05-06

出版者: Proceedings of the National Academy of Sciences

掲載誌:

• Proceedings of the National Academy of Sciences (ISSN: 00278424) vol. 122 issue. 18 e2422135122

研究助成金:

• Taiwan Semiconductor Manufacturing Company 089401
• Taiwan Semiconductor Manufacturing Company 089401
• HHS | NIH | National Human Genome Research Institute R21HG010701
• HHS | NIH | National Human Genome Research Institute R21HG010701
• NSF | MPS | Division of Materials Research 2309037
• MEXT | Japan Society for the Promotion of Science 21H05233
• MEXT | Japan Society for the Promotion of Science 21H05233
• MEXT | Japan Society for the Promotion of Science 23H02052
• MEXT | Japan Society for the Promotion of Science 23H02052

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1073/pnas.2422135122

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更新時刻: 2026-02-17 08:30:24 +0900

MDRでの公開時刻: 2026-02-16 18:00:50 +0900