Article Current Research Trends and Hotspots in Radiotherapy Combined with Nanomaterials for Cancer Treatment: A Bibliometric and Visualization Analysis

Muyasha Abulimiti ; Shiqin Dai SAMURAI ORCID (National Institute for Materials Science) ; Ebara Mitsuhiro SAMURAI ORCID (National Institute for Materials Science) ; Yu Sugawara ; Yinuo Li ; Hideyuki Sakurai ; Yoshitaka Matsumoto

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Muyasha Abulimiti, Shiqin Dai, Ebara Mitsuhiro, Yu Sugawara, Yinuo Li, Hideyuki Sakurai, Yoshitaka Matsumoto. Current Research Trends and Hotspots in Radiotherapy Combined with Nanomaterials for Cancer Treatment: A Bibliometric and Visualization Analysis. Nanomaterials. 2025, 15 (15), 1205. https://doi.org/10.3390/nano15151205

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(abstract)

This study investigated the evolving trends, current research hotspots, and future directions of radiotherapy combined with nanobiomaterials through a bibliometric analysis. Publications related to nanobiomaterials used in radiotherapy between 2004 and 2024 were retrieved from theWeb of Science Core Collection database and analyzed using VOSviewer, R, and CiteSpace. China emerged as the leading contributor, accounting for 1051 publications (50.41%), followed by the USA. Liu Zhuang is the most productive author in this field. American Chemical Society (ACS) Nano published the most influential articles and accumulated the highest number of citations. Advanced Targeted Therapies in Cancer: Drug Nanocarriers, the Future of Chemotherapy was the most cited, with 1255 citations. Citation bursts have revealed emerging research trends in targeted delivery, cellular studies, co-delivery strategies, immunogenic cell death, polymeric nanoparticles, tumor research, and drug delivery systems, indicating potential avenues for future research. Over the past two decades, nanomaterials for radiotherapy have gained substantial attention. Key areas of focus include enhancing the efficacy of radiotherapy, achieving targeted drug delivery, minimizing adverse effects, and integrating nanomaterials with other therapeutic modalities. Future investigations are expected to improve the precision of radiotherapy, augment radiation effects, and optimize the tumor microenvironment.

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Keyword: radiotherapy, nanofibers, cancer

Date published: 2025-08-06

Publisher: MDPI AG

Journal:

  • Nanomaterials (ISSN: 20794991) vol. 15 issue. 15 1205

Funding:

  • Japan–China Sasakawa Medical Fellowship and JST SPRING JPMJSP2124

Manuscript type: Publisher's version (Version of record)

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First published URL: https://doi.org/10.3390/nano15151205

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Updated at: 2025-12-16 10:08:15 +0900

Published on MDR: 2025-12-19 14:11:43 +0900

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