Article Functionalization of viscoelastic gels with decellularized extracellular matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration

Debabrata Palai ; Hana Yasue ; Shima Ito SAMURAI ORCID ; Hiyori Komatsu SAMURAI ORCID ; Tetsushi Taguchi SAMURAI ORCID ; Akihiro Nishiguchi SAMURAI ORCID

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Debabrata Palai, Hana Yasue, Shima Ito, Hiyori Komatsu, Tetsushi Taguchi, Akihiro Nishiguchi. Functionalization of viscoelastic gels with decellularized extracellular matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration. Biomaterials Science. 2025, 13 (13), 3576-3584. https://doi.org/10.1039/d5bm00394f

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(abstract)

Natural extracellular matrix (ECM) is viscoelastic and fibrous, which are crucial characteristics for controlling cellular responses. In contrast, synthetic gels are mostly elastic and less effective at promoting mechanotransduction. Thus, design of gels that provide mechanical and biochemical cues for tissue regeneration need to be explored. In this study, we aimed to develop viscoelatic gels functionalized with decellularized ECM (dECM) microparticles for tissue regeneration. The incorporation of dECM microparticles into gels improved not only the tissue adhesive properties of the gels and but also their viscoelasticity. The modulation of the mechanical properties of the gels elicited cell adhesion and spreading. Moreover, the functionalization of viscoelastic gels with dECM microparticles promoted tissue regeneration in volumetric muscle-loss models. This approach would be powerful tool as functional scaffolds with sufficient mechanical and biological properties to facilitate tissue regeneration.

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Keyword: Tissue regeneration, Hydrogel

Date published: 2025-04-29

Publisher: Royal Society of Chemistry (RSC)

Journal:

  • Biomaterials Science (ISSN: 20474830) vol. 13 issue. 13 p. 3576-3584

Funding:

  • Japan Society for the Promotion of Science 22H03962
  • Japan Society for the Promotion of Science 23H01718
  • Japan Society for the Promotion of Science 23K26411
  • Japan Society for the Promotion of Science 24K21677
  • Uehara Memorial Foundation

Manuscript type: Publisher's version (Version of record)

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First published URL: https://doi.org/10.1039/d5bm00394f

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Updated at: 2025-06-26 12:30:31 +0900

Published on MDR: 2025-06-26 12:26:34 +0900

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