Download file (3.08MB)
Download as zip (2.95MB)

コレクション

引用

説明:

Natural extracellular matrix (ECM) is viscoelastic and fibrous, which are crucial characteristics for controlling cellular responses. In contrast, synthetic gels are mostly elastic and less effective at promoting mechanotransduction. Thus, design of gels that provide mechanical and biochemical cues for tissue regeneration need to be explored. In this study, we aimed to develop viscoelatic gels functionalized with decellularized ECM (dECM) microparticles for tissue regeneration. The incorporation of dECM microparticles into gels improved not only the tissue adhesive properties of the gels and but also their viscoelasticity. The modulation of the mechanical properties of the gels elicited cell adhesion and spreading. Moreover, the functionalization of viscoelastic gels with dECM microparticles promoted tissue regeneration in volumetric muscle-loss models. This approach would be powerful tool as functional scaffolds with sufficient mechanical and biological properties to facilitate tissue regeneration.

権利情報:

• cc-by-nc-3.0
  

キーワード: Tissue regeneration, Hydrogel

刊行年月日: 2025-04-29

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• Biomaterials Science (ISSN: 20474830) vol. 13 issue. 13 p. 3576-3584

研究助成金:

• Japan Society for the Promotion of Science 22H03962
• Japan Society for the Promotion of Science 23H01718
• Japan Society for the Promotion of Science 23K26411
• Japan Society for the Promotion of Science 24K21677
• Uehara Memorial Foundation

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d5bm00394f

関連資料:

その他の識別子:

連絡先:

更新時刻: 2025-06-26 12:30:31 +0900

MDRでの公開時刻: 2025-06-26 12:26:34 +0900