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A hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) loaded with silver nanoparticles (AgNPs) was prepared by immersion of HAp/Col powder in the AgNPs solution. The adsorption-desorption properties on the preparation process were investigated, followed by the evaluation of antibacterial activities and cytotoxicity. Adsorption of AgNPs on HAp/Col powder was almost finished at 240 min after mixing. Adsorption isotherm revealed that maximum adsorption amount was 1621.9 mg/g with the best fitted model, Dubinin-Radushkevich adsorption model. The AgNPs-loaded HAp/Col membrane prepared by immersion into 1.6 µg/mL and 6.3 µg/mL AgNPs colloidal solution demonstrated no survival of Escherichia coli and Staphylococcus aureus, respectively. Using human osteoblastic cell line, MG-63, no significant cytotoxicity was observed for the AgNPs-loaded HAp/Col membrane prepared with 6.3-12.5 µg/mL AgNPs colloidal solution. These results suggested that AgNPs-loaded HAp/Col would be a good candidate for antibacterial bone void fillers and coating materials for orthopedic and dental implants.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: Hydroxyapatite/collagen bone-like nanocomposite, Silver nanoparticles, Anti-microbial, Cytotoxicity, Bone void filler

Date published: 2026-06-01

Publisher: Springer Science and Business Media LLC

Journal:

• Scientific Reports (ISSN: 20452322) vol. 16 issue. 1

Funding:

• Japan Agency for Medical Research and Development 21im0210221h0203

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1038/s41598-026-54878-2

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Updated at: 2026-08-19 13:49:18 +0900

Published on MDR: 2026-08-19 16:24:47 +0900