Article Use of an Ion-exchange Adduct of Synthetic Hectorite and Chiral Copper(II) Complex as a Packing Material for Chromatographic Resolution

Akihiko Yamagishi (Toho University) ; Kenji Tamura SAMURAI ORCID (Research Center for Electronic and Optical Materials/Functional Materials Field/Environmental Circulation Composite Materials Group, National Institute for Materials ScienceROR) ; Masumi Kamon (Research Center for Electronic and Optical Materials/Functional Materials Field/Environmental Circulation Composite Materials Group, National Institute for Materials ScienceROR) ; Jun Yoshida (Nihon University) ; Hisako Sato (Ehime University)

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Akihiko Yamagishi, Kenji Tamura, Masumi Kamon, Jun Yoshida, Hisako Sato. Use of an Ion-exchange Adduct of Synthetic Hectorite and Chiral Copper(II) Complex as a Packing Material for Chromatographic Resolution. APPLIED CLAY SCIENCE. 2024, 251 (), 107290. https://doi.org/10.1016/j.clay.2024.107290
SAMURAI

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(abstract)

A spherically shaped particle of synthetic hectorite (denoted as Na-HEC) was ion-exchanged with a divalent Cu(II) complex, [Cu(SS-oxa)]2+ (SS-oxa = SS-2,2′-isopropylidene-bis(4-phenyl-2-oxazoline)). The material is denoted as [Cu(SS-oxa)]2+/HEC. A column for high performance liquid chromatography (HPLC) was prepared by packing 4.0 g of [Cu(SS-oxa)]2+/HEC into a stainless tube (25 cm x 0.4 cm (i.d.)). When tris(acetylacetonato)cobalt(III) (denoted as [Co(acac)3]) was eluted by methanol at the flow rate of 0.2 mLmin-1 and 4 oC, the compound was separated to Δ- and Λ-enantiomers nearly to the baseline separation. Organic molecules with two hydroxyl groups such as 1,1’-binaphthyl-2,2’-diol were also resolved partially. The results promised the practical utility of the clay column chromatography for obtaining enantiomeric compounds.

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Keyword: Ion-exchange adducts, Synthetic hectorite, Chiral copper(II) complexes, High performance liquid chromatograph, Optical resolution

Date published: 2024-02-20

Publisher: Elsevier

Journal:

  • APPLIED CLAY SCIENCE (ISSN: 01691317) vol. 251 107290

Funding:

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4410

First published URL: https://doi.org/10.1016/j.clay.2024.107290

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Updated at: 2026-02-20 12:31:00 +0900

Published on MDR: 2026-02-20 10:23:04 +0900

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