Use of an Ion-exchange Adduct of Synthetic Hectorite and Chiral Copper(II) Complex as a Packing Material for Chromatographic Resolution

Akihiko Yamagishi; Kenji Tamura; Masumi Kamon; Jun Yoshida; Hisako Sato

doi:10.1016/j.clay.2024.107290

論文 Use of an Ion-exchange Adduct of Synthetic Hectorite and Chiral Copper(II) Complex as a Packing Material for Chromatographic Resolution

Akihiko Yamagishi (Toho University) ; Kenji Tamura (Research Center for Electronic and Optical Materials/Functional Materials Field/Environmental Circulation Composite Materials Group, National Institute for Materials Science) ; Masumi Kamon (Research Center for Electronic and Optical Materials/Functional Materials Field/Environmental Circulation Composite Materials Group, National Institute for Materials Science) ; Jun Yoshida (Nihon University) ; Hisako Sato (Ehime University)

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Akihiko Yamagishi, Kenji Tamura, Masumi Kamon, Jun Yoshida, Hisako Sato. Use of an Ion-exchange Adduct of Synthetic Hectorite and Chiral Copper(II) Complex as a Packing Material for Chromatographic Resolution. APPLIED CLAY SCIENCE. 2024, 251 (), 107290. https://doi.org/10.1016/j.clay.2024.107290

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(abstract)

A spherically shaped particle of synthetic hectorite (denoted as Na-HEC) was ion-exchanged with a divalent Cu(II) complex, [Cu(SS-oxa)]2+ (SS-oxa = SS-2,2′-isopropylidene-bis(4-phenyl-2-oxazoline)). The material is denoted as [Cu(SS-oxa)]2+/HEC. A column for high performance liquid chromatography (HPLC) was prepared by packing 4.0 g of [Cu(SS-oxa)]2+/HEC into a stainless tube (25 cm x 0.4 cm (i.d.)). When tris(acetylacetonato)cobalt(III) (denoted as [Co(acac)3]) was eluted by methanol at the flow rate of 0.2 mLmin-1 and 4 oC, the compound was separated to Δ- and Λ-enantiomers nearly to the baseline separation. Organic molecules with two hydroxyl groups such as 1,1’-binaphthyl-2,2’-diol were also resolved partially. The results promised the practical utility of the clay column chromatography for obtaining enantiomeric compounds.

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