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Description:

This article describes preparation of anti-decay self-setting pastes of hydroxyapatite/collagen (HAp/Col) utilizing (3-glycidoxypropyl)trimethoxysilane (GPTMS). The powder portion of the paste was ball-milled HAp/Col synthesized by the simultaneous titration method, and the liquid portion was GPTMS aqueous solution at a concentration of 0.1, 1.0 or 10 % in volume. The HAp/Col-GPTMS pastes were prepared by mixing the powder and liquid portions at powder/liquid (P/L) ratios ranging from 0.20 to 2.00 (g/cm3). The pastes with P/L ratios from 0.33 to 1.50 showed good handling properties, and their viscosities depended greatly on the P/L ratio. An animal test using porcine tibia demonstrated no harmful systemic or local symptoms, because the GPTMS concentration maintained acceptable levels for living tissues through dispersion with body fluid. The animal test also revealed that the paste was completely resorbed and substituted with newly formed bone after 12 weeks implantation.

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: Hydroxyapatite/collagen nanocomposite, (3-glycidoxypropyl) trimethoxysilane, bone paste, mechanical properties, biocompatibility

Date published: 2018-10-02

Publisher: Informa UK Limited

Journal:

• Journal of Asian Ceramic Societies (ISSN: 21870764) vol. 6 issue. 4 p. 322-331

Funding:

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1080/21870764.2018.1517712

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Updated at: 2024-03-19 16:56:01 +0900

Published on MDR: 2024-03-19 16:56:01 +0900