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説明:

This article describes preparation of anti-decay self-setting pastes of hydroxyapatite/collagen (HAp/Col) utilizing (3-glycidoxypropyl)trimethoxysilane (GPTMS). The powder portion of the paste was ball-milled HAp/Col synthesized by the simultaneous titration method, and the liquid portion was GPTMS aqueous solution at a concentration of 0.1, 1.0 or 10 % in volume. The HAp/Col-GPTMS pastes were prepared by mixing the powder and liquid portions at powder/liquid (P/L) ratios ranging from 0.20 to 2.00 (g/cm3). The pastes with P/L ratios from 0.33 to 1.50 showed good handling properties, and their viscosities depended greatly on the P/L ratio. An animal test using porcine tibia demonstrated no harmful systemic or local symptoms, because the GPTMS concentration maintained acceptable levels for living tissues through dispersion with body fluid. The animal test also revealed that the paste was completely resorbed and substituted with newly formed bone after 12 weeks implantation.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Hydroxyapatite/collagen nanocomposite, (3-glycidoxypropyl) trimethoxysilane, bone paste, mechanical properties, biocompatibility

刊行年月日: 2018-10-02

出版者: Informa UK Limited

掲載誌:

• Journal of Asian Ceramic Societies (ISSN: 21870764) vol. 6 issue. 4 p. 322-331

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1080/21870764.2018.1517712

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更新時刻: 2024-03-19 16:56:01 +0900

MDRでの公開時刻: 2024-03-19 16:56:01 +0900