Article Sprayable gelatin microparticles prevent delayed gastric bleeding in an anticoagulated swine model

Shohei Uehara ; Fumisato Sasaki ; Hidehito Maeda ; Makoto Hinokuchi ; Akihito Tanaka ; Shiho Arima ; Shinichi Hashimoto ; Shuji Kanmura ; Hisashi Sahara ; Yasuko Kobayashi ; Akihiro Nishiguchi SAMURAI ORCID (National Institute for Materials Science) ; Tetsushi Taguchi SAMURAI ORCID (National Institute for Materials Science)

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Shohei Uehara, Fumisato Sasaki, Hidehito Maeda, Makoto Hinokuchi, Akihito Tanaka, Shiho Arima, Shinichi Hashimoto, Shuji Kanmura, Hisashi Sahara, Yasuko Kobayashi, Akihiro Nishiguchi, Tetsushi Taguchi. Sprayable gelatin microparticles prevent delayed gastric bleeding in an anticoagulated swine model. Scientific Reports. 2026, 16 (1), 7075. https://doi.org/10.1038/s41598-026-38423-9

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(abstract)

Delayed bleeding following endoscopic mucosal resection or endoscopic submucosal dissection is a serious concern in patients receiving anticoagulant therapy. We previously established an experimental animal model of delayed gastric bleeding following endoscopic resection under controlled anticoagulation. In this study, we aimed to evaluate the potential preventive effect of hydrophobized microparticles (hMPs), a novel sprayable wound-covering material derived from Alaska pollock gelatin, in preventing delayed bleeding.

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Keyword: Endoscopic submucosal dissection, Endoscopic mucosal resection, Delayed gastric bleeding, Anticoagulation therapy, Hydrophobized microparticlesl, animal mode

Date published: 2026-02-03

Publisher: Springer Science and Business Media LLC

Journal:

  • Scientific Reports (ISSN: 20452322) vol. 16 issue. 1 7075

Funding:

  • Japan Society for the Promotion of Science KAKENHI
  • Japan Agency of Medical Research and Development

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.6218

First published URL: https://doi.org/10.1038/s41598-026-38423-9

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Updated at: 2026-03-16 09:03:32 +0900

Published on MDR: 2026-03-16 17:54:54 +0900

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