Sprayable gelatin microparticles prevent delayed gastric bleeding in an anticoagulated swine model

Shohei Uehara; Fumisato Sasaki; Hidehito Maeda; Makoto Hinokuchi; Akihito Tanaka; Shiho Arima; Shinichi Hashimoto; Shuji Kanmura; Hisashi Sahara; Yasuko Kobayashi; Akihiro Nishiguchi; Tetsushi Taguchi

doi:10.1038/s41598-026-38423-9

論文 Sprayable gelatin microparticles prevent delayed gastric bleeding in an anticoagulated swine model

Shohei Uehara ; Fumisato Sasaki ; Hidehito Maeda ; Makoto Hinokuchi ; Akihito Tanaka ; Shiho Arima ; Shinichi Hashimoto ; Shuji Kanmura ; Hisashi Sahara ; Yasuko Kobayashi ; Akihiro Nishiguchi (National Institute for Materials Science) ; Tetsushi Taguchi (National Institute for Materials Science)

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Shohei Uehara, Fumisato Sasaki, Hidehito Maeda, Makoto Hinokuchi, Akihito Tanaka, Shiho Arima, Shinichi Hashimoto, Shuji Kanmura, Hisashi Sahara, Yasuko Kobayashi, Akihiro Nishiguchi, Tetsushi Taguchi. Sprayable gelatin microparticles prevent delayed gastric bleeding in an anticoagulated swine model. Scientific Reports. 2026, 16 (1), 7075. https://doi.org/10.1038/s41598-026-38423-9

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(abstract)

Delayed bleeding following endoscopic mucosal resection or endoscopic submucosal dissection is a serious concern in patients receiving anticoagulant therapy. We previously established an experimental animal model of delayed gastric bleeding following endoscopic resection under controlled anticoagulation. In this study, we aimed to evaluate the potential preventive effect of hydrophobized microparticles (hMPs), a novel sprayable wound-covering material derived from Alaska pollock gelatin, in preventing delayed bleeding.

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