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Description:

In this study, multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia. The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes, doxorubicin-encapsulated thermoresponsive liposomes and Fe3O4 nanoparticles. The scaffolds released microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs, and also showed excellent hyperthermia effects under alternating magnetic field irradiation. In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the synergistic effect of magnetic hyperthermia and sensitizing chemotherapy. Additionally, the scaffolds supported the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: Multifunctional scaffolds, Magnetic hyperthermia, Sensitizing chemotherapy, Tissue regeneration, Matrix metalloproteinase responsive, microRNA encapsulated liposomes

Date published: 2024-10-19

Publisher: Elsevier BV

Journal:

• Bioactive Materials (ISSN: 2452199X) vol. 44 p. 205-219

Funding:

• Japan Society for the Promotion of Science 19H04475
• Japan Society for the Promotion of Science 21H03830
• Japan Society for the Promotion of Science 22K19926
• Japan Society for the Promotion of Science 24K03289

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1016/j.bioactmat.2024.10.011

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Updated at: 2024-10-25 16:30:53 +0900

Published on MDR: 2024-10-25 16:30:53 +0900