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説明:

In the current work, we take advantage of protein accumulation to distinguish senescence cells from other cells. The protein concentration is visualized by recording the phase difference using the quantitative phase microscopy (QPM). Our live QPM observations on breast cancer cells confirms that senescent cells exhibit a higher refractive index compared to cells in normal growth and quiescent states, attributed to the accumulation of undigested lysosomal protein cargo.

権利情報:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

キーワード: Label-free classification, Growth-arrested state, Quantitative phase microscopy

刊行年月日: 2025-12-31

出版者: Informa UK Limited

掲載誌:

• Science and Technology of Advanced Materials: Methods (ISSN: 27660400) vol. 5 issue. 1 2525061

研究助成金:

• JST FOREST Program JPMJFR2327
• Grant-in-Aid for Transformative Research Areas JP20H05877
• Japan Society for the Promotion of Science

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1080/27660400.2025.2525061

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更新時刻: 2025-08-04 12:30:27 +0900

MDRでの公開時刻: 2025-08-04 12:17:08 +0900