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Description:

Inosine pranobex (InP), an immunomodulatory drug approved for clinical use worldwide, is a potential adjuvant for cancer vaccines with a low clinical translation barrier. However, the administration of soluble InP agents in free format is associated with drawbacks of a short half-life period and limited efficacy. In this study, a rapid self-assembly approach was proposed for the synthesis of cancer vaccines due to the coordination interaction of ferric ion and acedoben (Ace) in InP. The self-assembled cancer vaccines can be readily adjusted from the microscale to the nanoscale, with shapes including rods, fibers, and spheres. Herein, Fe-Ace coordination complexes not only serve as carriers for tumor antigens, but also enhance antigen-specific antitumor immunity due to their intrinsic adjuvant properties. Nanofibrous self-assembled cancer vaccines based on Fe-Ace coordination complexes more effectively induced an antitumor immune response, exerted a remarkable therapeutic effect, and inhibited the tumor growth at distant site in vivo, compared to free InP and other self-assembled cancer vaccines. The presented work provides a promising strategy for the rapid manufacture of InP-derived self-adjuvant, self-carrier, and self-assembled vaccines for cancer immunotherapy.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

  © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

Keyword: cancer immunotherapy, therapeutic cancer vaccines, coordination complexes, inosine pranobex, self-assembly

Date published: 2024-06-26

Publisher: Elsevier BV

Journal:

• Applied Materials Today (ISSN: 23529407) vol. 39 102299

Funding:

• Ministry of Education, Culture, Sports, Science and Technology JPMXP1223NM5201
• Takeda Science Foundation
• National Institute for Materials Science
• Japan Society for the Promotion of Science 22K20517
• Japan Society for the Promotion of Science 23K04555

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4760

First published URL: https://doi.org/10.1016/j.apmt.2024.102299

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Updated at: 2024-09-19 11:56:10 +0900

Published on MDR: 2026-06-26 08:27:44 +0900