Article Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis

Mayu Ohira ; Moe Kitamura ; Hiroyo Iwasaki ; Haruko Ohta‐Okano ; Hiyori Tsujii ; Reika Nakamura ; Takuya Nakazawa ; Akihiro Nishiguchi SAMURAI ORCID (National Institute for Materials Science) ; Masaya Yamamoto ; Kensuke Osada ; Shinichi Toyooka ; Horacio Cabral ; Atsushi Masamune ; Mitsunobu R. Kano ; Hiroyoshi Y. Tanaka

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Mayu Ohira, Moe Kitamura, Hiroyo Iwasaki, Haruko Ohta‐Okano, Hiyori Tsujii, Reika Nakamura, Takuya Nakazawa, Akihiro Nishiguchi, Masaya Yamamoto, Kensuke Osada, Shinichi Toyooka, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano, Hiroyoshi Y. Tanaka. Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis. Small. 2025, 21 (50), e06926. https://doi.org/10.1002/smll.202506926

Description:

(abstract)

In this paper, we present that collagen signaling via DDR1 exacerbates barriers to macromolecular drug delivery in a 3D model of pancreatic cancer fibrosis.

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Keyword: 3D model, cancer

Date published: 2025-10-31

Publisher: Wiley

Journal:

  • Small (ISSN: 16136810) vol. 21 issue. 50 e06926

Funding:

  • Japan Society for the Promotion of Science JP24H00787
  • Japan Society for the Promotion of Science JP21H03832
  • Japan Society for the Promotion of Science JP21K19014
  • Japan Society for the Promotion of Science JP23K24312
  • Japan Society for the Promotion of Science JP23H02653
  • Japan Society for the Promotion of Science JP26293119
  • Japan Society for the Promotion of Science JP23K06279
  • Japan Society for the Promotion of Science JP20K16989
  • Okayama University
  • Inamori Foundation
  • Hokuto Foundation for Bioscience
  • Japan Foundation for Applied Enzymology
  • Pancreas Research Foundation of Japan
  • Ryobi Teien Memory Foundation
  • Japan Science and Technology Agency JPMJPF2202

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1002/smll.202506926

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Updated at: 2026-01-06 16:45:26 +0900

Published on MDR: 2025-12-05 16:24:31 +0900

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