Article Effect of sprayable, highly adhesive hydrophobized gelatin microparticles on esophageal stenosis after endoscopic submucosal dissection: an experimental study in a swine model

Hiroki Yano ; Fumisato Sasaki ORCID ; Hidehito Maeda ; Shohei Uehara ; Masayuki Kabayama ; Yusuke Fujino ; Akihito Tanaka ; Makoto Hinokuchi ; Shiho Arima ; Shinichi Hashimoto ; Shuji Kanmura ; Shima Ito ; Akihiro Nishiguchi SAMURAI ORCID ; Tetsushi Taguchi SAMURAI ORCID ; Akio Ido

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Hiroki Yano, Fumisato Sasaki, Hidehito Maeda, Shohei Uehara, Masayuki Kabayama, Yusuke Fujino, Akihito Tanaka, Makoto Hinokuchi, Shiho Arima, Shinichi Hashimoto, Shuji Kanmura, Shima Ito, Akihiro Nishiguchi, Tetsushi Taguchi, Akio Ido. Effect of sprayable, highly adhesive hydrophobized gelatin microparticles on esophageal stenosis after endoscopic submucosal dissection: an experimental study in a swine model. Esophagus. 2024, 22 (1), 95-104. https://doi.org/10.1007/s10388-024-01090-8

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(abstract)

Esophageal mucosal resection for superficial esophageal cancer can lead to postoperative esophageal stricture, with current preventive measures being insufficient. Sprayable wound dressings containing hydrophobized microparticles exhibit strong adhesion. This study aimed to investigate the preventive effects of hydrophobized microparticles on esophageal stenosis following endoscopic submucosal dissection. Spraying of hydrophobized microparticles was easily performed using an existing endoscopic spraying device. The esophageal stricture rate was significantly lower in the sprayed group than in the non-sprayed group (76.1% versus 90.6%, p<0.05). The sprayed group showed suppression of inflammatory cell infiltration in the submucosal layer (p<0.01) and thickening of the muscular layer (p<0.01).

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Keyword: Alaska pollock-derived gelatin; Particle

Date published: 2024-10-15

Publisher: Springer Science and Business Media LLC

Journal:

  • Esophagus (ISSN: 16129059) vol. 22 issue. 1 p. 95-104

Funding:

  • Translational Research Program TR-SPRINT (Strategic PRomotion for practical application of INnovative medical Technology) of the Japan Agency of Medical Research and Development 20 lm0203114h0001
  • Japan Society for the Promotion of Science KAKENHI 19K17467
  • Japan Society for the Promotion of Science KAKENHI 20H0247
  • Kagoshima University

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5425

First published URL: https://doi.org/10.1007/s10388-024-01090-8

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Updated at: 2025-04-16 16:30:07 +0900

Published on MDR: 2025-04-16 14:29:28 +0900

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