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Esophageal mucosal resection for superficial esophageal cancer can lead to postoperative esophageal stricture, with current preventive measures being insufficient. Sprayable wound dressings containing hydrophobized microparticles exhibit strong adhesion. This study aimed to investigate the preventive effects of hydrophobized microparticles on esophageal stenosis following endoscopic submucosal dissection. Spraying of hydrophobized microparticles was easily performed using an existing endoscopic spraying device. The esophageal stricture rate was significantly lower in the sprayed group than in the non-sprayed group (76.1% versus 90.6%, p<0.05). The sprayed group showed suppression of inflammatory cell infiltration in the submucosal layer (p<0.01) and thickening of the muscular layer (p<0.01).

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Alaska pollock-derived gelatin; Particle

刊行年月日: 2024-10-15

出版者: Springer Science and Business Media LLC

掲載誌:

• Esophagus (ISSN: 16129059) vol. 22 issue. 1 p. 95-104

研究助成金:

• Translational Research Program TR-SPRINT (Strategic PRomotion for practical application of INnovative medical Technology) of the Japan Agency of Medical Research and Development 20 lm0203114h0001
• Japan Society for the Promotion of Science KAKENHI 19K17467
• Japan Society for the Promotion of Science KAKENHI 20H0247
• Kagoshima University

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5425

公開URL: https://doi.org/10.1007/s10388-024-01090-8

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更新時刻: 2025-04-16 16:30:07 +0900

MDRでの公開時刻: 2025-04-16 14:29:28 +0900