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Disruption of the dura mater occurs in neurosurgery and leads to the cerebrospinal fluid (CSF) leakage. A fibrin sealant is most frequently applied to the ruptured site, but the problem is its lack of sealing strength. A novel biocompatible sealant composed of Alaska pollock-derived gelatin (ApGltn) has recently shown good burst strength and biocompatibility in a porcine aorta. The purpose of this study was to investigate the sealing strength and biocompatibility of the ApGltn sealant and fibrin sealant in a porcine and a rat disrupted dura injury model. The maximum burst strength of the ApGltn sealant was approximately 5.7 times higher than that of a fibrin sealant (82.4 ± 13.7 vs. 14.4 ± 9.6 mmHg, respectively; p < 0.001). Histological examination confirmed that the ApGltn sealant showed tight adhesion to the dura surface, while a gap was observed between the fibrin sealant and dura mater. Functional evaluation and histological examination in a rat model showed that dura maters repaired with ApGltn sealant showed similar recovery compared to repair with the fibrin sealant.

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  This is a pre-copyedited, author-produced version of an article accepted for publication in Spine. The published version of record Spine 49(13):p E200-E207, July 1, 2024. is available online at: https://doi.org/10.1097/BRS.0000000000004985.

Keyword: Alaska pollock-derived gelatin, Alaska pollock-derived gelatin sealant, burst strength, cerebrospinal fluid, cerebrospinal fluid leakage, dura, dural injury

Date published: 2024-07-01

Publisher: Ovid Technologies (Wolters Kluwer Health)

Journal:

• Spine (ISSN: 03622436) vol. 49 issue. 13 p. 0-0

Funding:

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4576

First published URL: https://doi.org/10.1097/brs.0000000000004985

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Updated at: 2025-07-01 12:30:33 +0900

Published on MDR: 2025-07-01 08:18:03 +0900