Article Electrospun EVOH/AST-120 hybrid nanofiber membranes for removal of indoxyl sulfate from blood

Makoto Sasaki SAMURAI ORCID (National Institute for Materials ScienceROR) ; Rieko Hirata ; Ayano Konagai ; Mitsuhiro Ebara SAMURAI ORCID (National Institute for Materials ScienceROR)

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Makoto Sasaki, Rieko Hirata, Ayano Konagai, Mitsuhiro Ebara. Electrospun EVOH/AST-120 hybrid nanofiber membranes for removal of indoxyl sulfate from blood. RSC Advances. 2024, 14 (36), 26596-26603. https://doi.org/10.1039/d4ra04501g
SAMURAI

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(abstract)

Nanofibers containing activated carbon using poly(ethylene-co-vinyl alcohol) (EVOH) were prepared to remove indoxyl sulfate (IS) from the blood. IS is a urinary toxin that is highly toxic and triggers the progression of chronic kidney disease (CKD). Here, nanofibers containing activated carbon (AST-120), which has been used practically as an adsorbent for indole (a precursor of IS), were fabricated via electrospinning for the adsorption and removal of IS from the blood. EVOH containing different ethylene ratios was used as the nanofiber material; moreover, the effect of the ethylene ratio on various properties of the nanofibers, such as surface wettability and the IS adsorption rate, was investigated. As a result, EVOH/AST-120 nanofibers comprising EVOH with a low ethylene ratio exhibited faster IS adsorption behavior. This adsorption behavior agreed well with the pseudo-second-order model, suggesting that the diffusion of IS into the nanofibers is the rate-limiting step of the process of adsorption. Furthermore, the nanofibers successfully reduced the IS concentration in the blood under circulating conditions. Therefore, these EVOH/AST-120 nanofibers are expected to greatly improve the prognosis of patients with CKD when used in combination with the current hemodialysis therapy as an IS-adsorbing filter.

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Keyword: Electrospinning, Nanofiber, Chronic Kidney Disease, Indoxyl sulfate, Hybrid maerial

Date published: 2024-08-22

Publisher: Royal Society of Chemistry (RSC)

Journal:

  • RSC Advances (ISSN: 20462069) vol. 14 issue. 36 p. 26596-26603

Funding:

  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science JP20H05877
  • Japan Society for the Promotion of Science JP23KJ0260

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1039/d4ra04501g

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Updated at: 2025-01-29 16:30:18 +0900

Published on MDR: 2025-01-29 16:30:19 +0900

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