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Nanofibers containing activated carbon using poly(ethylene-co-vinyl alcohol) (EVOH) were prepared to remove indoxyl sulfate (IS) from the blood. IS is a urinary toxin that is highly toxic and triggers the progression of chronic kidney disease (CKD). Here, nanofibers containing activated carbon (AST-120), which has been used practically as an adsorbent for indole (a precursor of IS), were fabricated via electrospinning for the adsorption and removal of IS from the blood. EVOH containing different ethylene ratios was used as the nanofiber material; moreover, the effect of the ethylene ratio on various properties of the nanofibers, such as surface wettability and the IS adsorption rate, was investigated. As a result, EVOH/AST-120 nanofibers comprising EVOH with a low ethylene ratio exhibited faster IS adsorption behavior. This adsorption behavior agreed well with the pseudo-second-order model, suggesting that the diffusion of IS into the nanofibers is the rate-limiting step of the process of adsorption. Furthermore, the nanofibers successfully reduced the IS concentration in the blood under circulating conditions. Therefore, these EVOH/AST-120 nanofibers are expected to greatly improve the prognosis of patients with CKD when used in combination with the current hemodialysis therapy as an IS-adsorbing filter.

権利情報:

• https://creativecommons.org/licenses/by-nc/3.0/legalcode
  

キーワード: Electrospinning, Nanofiber, Chronic Kidney Disease, Indoxyl sulfate, Hybrid maerial

刊行年月日: 2024-08-22

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• RSC Advances (ISSN: 20462069) vol. 14 issue. 36 p. 26596-26603

研究助成金:

• Ministry of Education, Culture, Sports, Science and Technology
• Japan Society for the Promotion of Science JP20H05877
• Japan Society for the Promotion of Science JP23KJ0260

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d4ra04501g

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更新時刻: 2025-01-29 16:30:18 +0900

MDRでの公開時刻: 2025-01-29 16:30:19 +0900