Enhanced ROS scavenging and tissue adhesive abilities in injectable hydrogels by protein modification with oligoethyleneimine

Debabrata Palai; Miho Ohta; Iga Cetnar; Tetsushi Taguchi; Akihiro Nishiguchi

doi:10.1039/d3bm02065g

論文 Enhanced ROS scavenging and tissue adhesive abilities in injectable hydrogels by protein modification with oligoethyleneimine

Debabrata Palai (National Institute for Materials Science) ; Miho Ohta ; Iga Cetnar ; Tetsushi Taguchi (National Institute for Materials Science) ; Akihiro Nishiguchi (National Institute for Materials Science)

59. Biomater. Sci.,2024,12,2312–2320.pdf

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Debabrata Palai, Miho Ohta, Iga Cetnar, Tetsushi Taguchi, Akihiro Nishiguchi. Enhanced ROS scavenging and tissue adhesive abilities in injectable hydrogels by protein modification with oligoethyleneimine. Biomaterials Science. 2024, 12 (9), 2312-2320. https://doi.org/10.1039/d3bm02065g

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(abstract)

Postsurgical treatment comprehensively benefits from the application of tissue-adhesive injectable hydrogels, which reduce postoperative complications by promoting wound closure and tissue regeneration. Although various hydrogels have been employed as clinical tissue adhesives, many exhibit deficiencies in adhesive strength under wet conditions or in immunomodulatory functions. Herein, we report the development of reactive oxygen species (ROS) scavenging and tissue-adhesive injectable hydrogels composed of polyamine-modified gelatin crosslinked with the 4-arm poly (ethylene glycol) crosslinker. Polyamine modified gelatin was particularly potent in suppressing the secretion of proinflammatory cytokines from stimulated primary macrophages. This effect is attributed to its ability to scavenge ROS and inhibit the nuclear translocation of nuclear factor kappa-B. Polyamine-modified gelatin-based hydrogels exhibited ROS scavenging abilities and enhanced tissue adhesive strength on collagen casing. Notably, the hydrogel demonstrated exceptional tissue adhesive properties in a wet environment, as evidenced by its performance using porcine small intestine tissue. This approach holds significant promise for designing immunomodulatory hydrogels with superior tissue adhesion strength compared to conventional medical materials, thereby contributing to advancements in minimally invasive surgical techniques.

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