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Uncontrollable hemorrhage resulting from trauma and surgical operation leads to high
mortality rates. Although several patch-type hemostatic materials have been used in
the clinic, achieving sufficient tissue adhesion and managing and preventing unwanted
tissue adhesion have been challenging. In this study, we designed a Janus tissue
adhesive hemostatic patch consisting of organic Alaska pollock gelatin (Org-ApGltn) as
a support layer and decanoyl group-modified ApGltn (C10-ApGltn) with pentaerythritol
poly(ethylene glycol) ether tetrasuccinimidyl glutarate (4S-PEG) as an adhesive layer,
named C10-ApGltn patch. The C10-ApGltn patch adhered onto the surface of blood
vessels by activated 4S-PEG and hydrophobic groups in C10-ApGltn through covalent
bond formation and physical interaction. The burst strength of the C10-ApGltn patch
was optimized in terms of the degree of substitution, the molecular weight of 4S-PEG,
the concentration of C10-ApGltn, and the NHS/NH2 ratio. The optimized C10-ApGltn
patch showed significantly higher burst strength with commercially available fibrin
sealant patch (TachoSil®). It also showed enzymatic degradability in a buffer solution
with collagenase. In a rat model of liver hemorrhage, the C10-ApGltn patch acted as a
sealant on the hemorrhage site and exhibited hemostatic efficacy comparable to that of
TachoSil®.

権利情報:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

キーワード: hemorrhage, hemostatic patch, Janus structure, Alaska pollock gelatin

刊行年月日: 2024-09-04

出版者: Elsevier BV

掲載誌:

• Biomaterials Advances (ISSN: 27729508) vol. 166 214028

研究助成金:

• Japan Society for the Promotion of Science

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4731

公開URL: https://doi.org/10.1016/j.bioadv.2024.214028

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更新時刻: 2024-09-09 17:25:58 +0900

MDRでの公開時刻: 2026-09-03 08:27:27 +0900