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説明:

Therapeutic cancer vaccines aim to train the immune system and elicit antitumor immune responses, which are expected to fill the unmet medical need of immune checkpoint inhibitors. Despite tremendous efforts over the past decades, it remains challenging to prepare personalized cancer vaccines using a facile and rapid approach due to tumor diversity. CpG-ODN is a promising immunoadjuvant in cancer immunotherapy, and many clinical trials have been performed or are ongoing. However, commonly used phosphorothioate-modified CpG ODN easily induces protein aggregation and its long-term side effects are concerned. Here, we designed hollow large-pore mesoporous organosilica with sulfide bond to simultaneously load unmodified CpG-ODN with guanine-quadruplex (G4) structures and different tumor antigens to prepare personalized cancer vaccines in a simple, fast, and effective way.

権利情報:

• In Copyright
  

キーワード: personalized, cancer nanovaccines, CpG-ODN, mesoporous organosilica

刊行年月日: 2024-06-01

出版者: American Society of Clinical Oncology (ASCO)

掲載誌:

• Journal of Clinical Oncology (ISSN: 0732183X) vol. 42 issue. 16_suppl

研究助成金:

• Japan Society for the Promotion of Science (JSPS), KAKENHI 23K04555 and 22K20517
• NIMS

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4762

公開URL: https://doi.org/10.1200/jco.2024.42.16_suppl.e14670

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更新時刻: 2025-05-30 08:30:07 +0900

MDRでの公開時刻: 2025-05-30 08:17:58 +0900