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International Center for Materials Nanoarchitectonics (WPI-MANA)

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[[Research Highlights Vol.14] Nanomechanical sensors detect cancer from breath](https://mdr.nims.go.jp/datasets/434d48b9-5ae8-4449-b5d1-7807289a4a02)

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2022/04/04 10:23 Nanomechanical sensors detect cancer from breath| MANAhttps://www.nims.go.jp/mana/research/highlights/vol14.html 1/2Previous  Index  NextResearch Highlights[Vol. 14]Nanomechanical sensors detect cancer from breath23 Apr, 2014An array of functionalised membrane-type surface stress sensors (MSS)distinguishes cancer patients from healthy people through a signatureresponse to breath samples.Figure : Principal Component Analysis case scores for breath samples of 4 healthy persons and 4cancer patients. Each sample has been measured 6 times (colored dots). A breath sample bagcontaining saturated water vapor has been measured as a control (blue dots). Healthy personscan be clearly distinguished from cancer patients (the ellipses are a guide to the eye).Cancer is the cause of 1 in 8 deaths worldwide, and early diagnosis can significantly improvesurvival rates. A collaboration of researchers in Switzerland and Japan has developed portablecancer detection units for non-invasive diagnosis. “We created an artificial nose that is sensitiveenough to diagnose head and neck cancer through analysis of the breath,” the researchersconcluded in a recent report on their work.The sensor design originates from conventional piezoresistive cantilever devices. Chemical layerscoated on cantilevers absorb specific compounds and cause deflection of the cantilevers. Thesedeflections can be measured through the change in electrical resistance at piezoresistors. However,these piezoresistive cantilever-type sensors have suffered from limited sensitivity. Recently,comprehensive structural optimization has led to a membrane-type surface stress sensor (MSS),achieving a significant improvement in sensitivity and stability. The MSS is composed of a thinhttps://www.nims.go.jp/mana/research/highlights/vol13.htmlhttps://www.nims.go.jp/mana/research/highlights/index.htmlhttps://www.nims.go.jp/mana/research/highlights/vol15.html2022/04/04 10:23 Nanomechanical sensors detect cancer from breath| MANAhttps://www.nims.go.jp/mana/research/highlights/vol14.html 2/2silicon membrane (typically 2.5 µm thick and 500 µm in diameter) suspended by fourpiezoresistive beams attached to the circumference.Frederic Loizeau at the Ecole Polytechnique Fédérale de Lausanne, Hans Peter Lang at theUniversity of Basel in Switzerland, Genki Yoshikawa at the National Institute of Materials Science inJapan and their colleagues fabricated an array of MSS and coated them with different polymers toabsorb various chemical compounds in breath samples. Reporting at the 26th IEEE InternationalConference on Micro Electro Mechanical Systems (IEEE MEMS 2013), the researchers presentedthat MSS could distinguish, in a double blind trial, the breath of four cancer patients from fourhealthy people.Reference"Piezoresistive membrane-type surface stress sensor arranged in arrays for cancer diagnosisthrough breath analysis"Frédéric Loizeau, Hans Peter Lang, Terunobu Akiyama, Sebastian Gautsch, Peter Vettiger, AndreasTonin, Genki Yoshikawa, Christoph Gerber, and Nico de RooijJournal : 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)DOI : 10.1109/MEMSYS.2013.6474318AffiliationsInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for MaterialsScience (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, JapanContact informationInternational Center for Materials Nanoarchitectonics(WPI-MANA)National Institute for Materials Science1-1 Namiki, Tsukuba, Ibaraki 305-0044 JapanPhone: +81-29-860-4710E-mail: mana-pr[AT]ml.nims.go.jphttps://ieeexplore.ieee.org/document/6474318