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[[Vol. 59]AFMтАЩs Probe Used to Induce Chemical Reactions at Specific Sites on Single Molecule_ WPI-MANA.pdf](https://mdr.nims.go.jp/filesets/db29fc70-1962-4a9b-8beb-d2ee87fb350c/download)

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International Center for Materials Nanoarchitectonics (WPI-MANA)

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[[Research Highlights Vol.59] AFM’s Probe Used to Induce Chemical Reactions at Specific Sites on Single Molecule](https://mdr.nims.go.jp/datasets/03b46098-9751-4581-9497-304e48eeb2fa)

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2022/03/31 16:22 AFM’s Probe Used to Induce Chemical Reactions at Specific Sites on Single Molecule| MANAhttps://www.nims.go.jp/mana/research/highlights/vol59.html 1/3Previous  Index  NextResearch Highlights[Vol. 59]AFM’s Probe Used to Induce Chemical Reactions at Specific Sites on SingleMolecule21 Aug, 2020A team at MANA has demonstrated controlled addition reactions at specific sites on asingle molecule by using an atomic force microscope’s (AFM) local probe at lowtemperature. This work enables the synthesis of functional carbon nanostructures thatcannot be obtained by conventional chemistry. Thanks to their superior electricalproperties, such nanostructures are expected to find applications in nanoelectronicdevices.The team synthesized three-dimensional graphene nanoribbons (3D-GNR) by on-surface chemicalreaction. Then, taking advantage of the AFM’s ability to conduct tip-induced assembly, theydemonstrated the nanoribbons’ capability as a framework for local probe chemistry. This couldallow sequential reactions, particularly addition reactions (in which two molecules combine tocreate a bigger one), by a local probe at the single-molecule level.https://www.nims.go.jp/mana/research/highlights/vol58.htmlhttps://www.nims.go.jp/mana/research/highlights/index.htmlhttps://www.nims.go.jp/mana/research/highlights/vol60.html2022/03/31 16:22 AFM’s Probe Used to Induce Chemical Reactions at Specific Sites on Single Molecule| MANAhttps://www.nims.go.jp/mana/research/highlights/vol59.html 2/3The AFM’s probe, terminated with a small carbon monoxide molecule, allows direct observation ofthe inner structures of both single molecules, as well as the products of on-surface chemicalreactions.It also allows researchers to conduct single molecule chemistry via tip-induced reactions. The localprobe can be used to generate highly reactive radical species by tip-induced dehydrogenation,dehalogenation or deoxidization on surfaces. However, since these organic redox reactions areconducted with planar molecules, the molecule-substrate interaction has to be reduced by insertingthin insulating films. In contrast, if a 3D hydrocarbon is used, the out-of-plane moiety can be usedfor local probe chemistry in a similar way to recent measurements of intermolecular interactions.The MANA team noted that direct addition reactions at specific sites like the ones theydemonstrated can advance chemistry toward synthesis of single compounds atom by atom. Suchextremely fine control offers the ability to create unprecedented new functional materials.This research was carried out by Shigeki Kawai* (Principal Researcher, Nano FunctionalityIntegration Group, Nano-System Field) and his collaborators.*Present affiliation: Group Leader, Nanoprobe Group, Nano Characterization Field, Research Centerfor Advanced Measurement and Characterization, NIMSReference“Three-dimensional Graphene Nanoribbons as a Framework for Molecular Assembly and LocalProbe Chemistry”Shigeki Kawai, Ondřej Krejči, Tomohiko Nishiuchi, Keisuke Sahara, Takuya Kodama, Rémy Pawlak,Ernst Meyer, Takashi Kubo, and Adam S. FosterJournal : Science Advances [February 28, 2020]DOI : 10.1126/sciadv.aay8913(Press release on this research)"Chemical Reactions at Specific Molecular Sites under a Microscope” (29 February 2020)https://www.nims.go.jp/mana/news_room/press/2020022901.html（MANA E-BULLETIN）https://www.nims.go.jp/mana/ebulletin/AffiliationsInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for MaterialsScience (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, JapanContact informationInternational Center for Materials Nanoarchitectonics(WPI-MANA)https://samurai.nims.go.jp/profiles/kawai_shigeki?locale=enhttps://samurai.nims.go.jp/profiles/kawai_shigeki?locale=enhttps://doi.org/10.1126/sciadv.aay8913https://www.nims.go.jp/mana/news_room/press/2020022901.htmlhttps://www.nims.go.jp/mana/ebulletin/2022/03/31 16:22 AFM’s Probe Used to Induce Chemical Reactions at Specific Sites on Single Molecule| MANAhttps://www.nims.go.jp/mana/research/highlights/vol59.html 3/3National Institute for Materials Science1-1 Namiki, Tsukuba, Ibaraki 305-0044 JapanPhone: +81-29-860-4710E-mail: mana-pr[AT]ml.nims.go.jp