# Fileset [STAM-2025-0435_data.zip](https://mdr.nims.go.jp/filesets/b43e93f4-00ad-4e9a-929b-0af7380ee52d/download) ## Creator Riki Toita, Yuki Shimizu, Jeong-Hun Kang ## Rights [Creative Commons BY Attribution 4.0 International](https://creativecommons.org/licenses/by/4.0/) ## Other metadata [Distinct macrophage uptake of engineered and biological particles driven by host age and sex](https://mdr.nims.go.jp/datasets/bbabbd10-f452-4980-ae0f-615e38ca6acd) ## Fulltext STAM-2025-0435_data/STAM-2025-0435.xlsxFigure 1 Plain Particles NH2 Particles COOH Particles E. coli S. aureus Zymosan Size (nm) S M Size (nm) S M Size (nm) S M L Size (nm) Size (nm) Size (nm) 0.4 0 0 0.4 0 0 0.4 0 0 0 0.4 0 0.4 0 0.4 0 0.463 0 0 0.463 0 0 0.463 0 0 0 0.463 0 0.463 0 0.463 0 0.536 0 0 0.536 0 0 0.536 0 0 0 0.536 0 0.536 0 0.536 0 0.621 0 0 0.621 0 0 0.621 0 0 0 0.621 0 0.621 0 0.621 0 0.719 0 0 0.719 0 0 0.719 0 0 0 0.719 0 0.719 0 0.719 0 0.833 0 0 0.833 0 0 0.833 0 0 0 0.833 0 0.833 0 0.833 0 0.965 0 0 0.965 0 0 0.965 0 0 0 0.965 0 0.965 0 0.965 0 1.12 0 0 1.12 0 0 1.12 0 0 0 1.12 0 1.12 0 1.12 0 1.29 0 0 1.29 0 0 1.29 0 0 0 1.29 0 1.29 0 1.29 0 1.5 0 0 1.5 0 0 1.5 0 0 0 1.5 0 1.5 0 1.5 0 1.74 0 0 1.74 0 0 1.74 0 0 0 1.74 0 1.74 0 1.74 0 2.01 0 0 2.01 0 0 2.01 0 0 0 2.01 0 2.01 0 2.01 0 2.33 0 0 2.33 0 0 2.33 0 0 0 2.33 0 2.33 0 2.33 0 2.7 0 0 2.7 0 0 2.7 0 0 0 2.7 0 2.7 0 2.7 0 3.12 0 0 3.12 0 0 3.12 0 0 0 3.12 0 3.12 0 3.12 0 3.62 0 0 3.62 0 0 3.62 0 0 0 3.62 0 3.62 0 3.62 0 4.19 0 0 4.19 0 0 4.19 0 0 0 4.19 0 4.19 0 4.19 0 4.85 0 0 4.85 0 0 4.85 0 0 0 4.85 0 4.85 0 4.85 0 5.61 0 0 5.61 0 0 5.61 0 0 0 5.61 0 5.61 0 5.61 0 6.5 0 0 6.5 0 0 6.5 0 0 0 6.5 0 6.5 0 6.5 0 7.53 0 0 7.53 0 0 7.53 0 0 0 7.53 0 7.53 0 7.53 0 8.72 0 0 8.72 0 0 8.72 0 0 0 8.72 0 8.72 0 8.72 0 10.1 0 0 10.1 0 0 10.1 0 0 0 10.1 0 10.1 0 10.1 0 11.7 0 0 11.7 0 0 11.7 0 0 0 11.7 0 11.7 0 11.7 0 13.5 0 0 13.5 0.342 0 13.5 0.508 0 0 13.5 0 13.5 0 13.5 0 15.7 0 0 15.7 1.32 0 15.7 1.67 0 0 15.7 0 15.7 0 15.7 0 18.2 0 0 18.2 3.02 0 18.2 3.37 0 0 18.2 0 18.2 0 18.2 0 21 0 0 21 5.28 0 21 5.39 0 0 21 0 21 0 21 0 24.4 0 0 24.4 7.8 0 24.4 7.43 0 0 24.4 0 24.4 0 24.4 0 28.2 0.241 0 28.2 10.1 0 28.2 9.2 0 0 28.2 0 28.2 0 28.2 0 32.7 2.16 0 32.7 11.9 0 32.7 10.5 0 0 32.7 0 32.7 0 32.7 0 37.8 5.5 0 37.8 12.7 0 37.8 11.1 0 0 37.8 0 37.8 0 37.8 0 43.8 9.3 0 43.8 12.6 0 43.8 11 0 0 43.8 0 43.8 0 43.8 0 50.7 12.6 0 50.7 11.3 0 50.7 10.3 0 0 50.7 0 50.7 0 50.7 0 58.8 14.5 0 58.8 9.33 0 58.8 9.02 0 0 58.8 0 58.8 0 58.8 0 68.1 14.9 0 68.1 6.86 0 68.1 7.37 0 0 68.1 0 68.1 0 68.1 0 78.8 13.6 0 78.8 4.36 0 78.8 5.56 0 0 78.8 0 78.8 0 78.8 0 91.3 11.2 0 91.3 2.22 0 91.3 3.79 0 0 91.3 0 91.3 0 91.3 0 106 8.06 0 106 0.75 0 106 2.26 0 0 106 0 106 0 106 0 122 4.94 0 122 0.0692 0 122 1.1 0 0 122 0 122 0 122 0 142 2.35 0 142 0 0 142 0.37 0 0 142 0 142 0 142 0 164 0.681 4.99 164 0 0 164 0.0449 1.73 0 164 0 164 0 164 0 190 0 14.2 190 0 3.01 190 0 6.66 0 190 0 190 0 190 0 220 0 22.2 220 0 10.7 220 0 12.9 0 220 0 220 0 220 0 255 0 24.3 255 0 18.9 255 0 17.9 0 255 0 255 0 255 0 295 0 19.7 295 0 23.2 295 0 19.7 0 295 0 295 0 295 0 342 0 11.2 342 0 21.4 342 0 17.8 0 342 0 342 0 342 0 396 0 3.39 396 0 14.8 396 0 13.2 0 396 0 396 0.686 396 0 459 0 0 459 0 6.74 459 0 7.44 0 459 0 459 2.5 459 0 531 0 0 531 0 1.2 531 0 2.61 0 531 0 531 5.24 531 0 615 0 0 615 0 0 615 0 0.121 0 615 0 615 8.34 615 0 712 0 0 712 0 0 712 0 0 0 712 0 712 11.2 712 0 825 0 0 825 0 0 825 0 0 0 825 0.894 825 13.1 825 0 955 0 0 955 0 0 955 0 0 0 955 33 955 13.8 955 0 1110 0 0 1110 0 0 1110 0 0 0 1110 44.3 1110 13.2 1110 0 1280 0 0 1280 0 0 1280 0 0 0 1280 21.8 1280 11.5 1280 0 1480 0 0 1480 0 0 1480 0 0 0 1480 0 1480 8.94 1480 0 1720 0 0 1720 0 0 1720 0 0 0 1720 0 1720 6.12 1720 0 1990 0 0 1990 0 0 1990 0 0 0 1990 0 1990 3.51 1990 0 2300 0 0 2300 0 0 2300 0 0 6.29 2300 0 2300 1.53 2300 0 2670 0 0 2670 0 0 2670 0 0 20.7 2670 0 2670 0.375 2670 0 3090 0 0 3090 0 0 3090 0 0 30.3 3090 0 3090 0 3090 0 3580 0 0 3580 0 0 3580 0 0 26.9 3580 0 3580 0 3580 0 4150 0 0 4150 0 0 4150 0 0 13.8 4150 0 4150 0 4150 0.677 4800 0 0 4800 0 0 4800 0 0 1.99 4800 0 4800 0 4800 37.9 5560 0 0 5560 0 0 5560 0 0 0 5560 0 5560 0 5560 61.4 6440 0 0 6440 0 0 6440 0 0 0 6440 0 6440 0 6440 0 7460 0 0 7460 0 0 7460 0 0 0 7460 0 7460 0 7460 0 8630 0 0 8630 0 0 8630 0 0 0 8630 0 8630 0 8630 0Figure 2B S-COOH Male-Y Male-MA Male-O Female-Y Female-MA Female-O 4 h 0.087 0.085 0.08 0.068 0.068 0.062 0.048 0.045 0.043 0.1 0.088 0.082 0.075 0.076 0.072 0.083 0.086 0.089 24 h 1.131 0.88 0.883 0.797 0.783 0.798 0.778 0.792 0.797 0.793 0.893 0.72 0.734 0.714 0.712 0.669 0.644 0.604 M-COOH Male-Y Male-MA Male-O Female-Y Female-MA Female-O 4 h 0.154 0.114 0.111 0.102 0.095 0.091 0.075 0.07 0.073 0.117 0.088 0.089 0.108 0.103 0.1 0.111 0.098 0.094 24 h 1.067 1.096 0.837 0.782 0.821 0.781 0.77 0.739 0.724 0.974 0.73 0.776 0.794 0.771 0.76 0.712 0.703 0.656 L-COOH Male-Y Male-MA Male-O Female-Y Female-MA Female-O 4 h 0.008 0.007 0.05 0.073 0.068 0.09 0.076 0.069 0.09 0.034 0.052 0.097 0.079 0.095 0.12 0.138 0.131 0.089 24 h 1.098 0.96 0.942 0.488 0.527 0.557 0.491 0.466 0.472 1.322 1.021 0.881 0.514 0.463 0.558 0.468 0.534 0.487 M-NH2 Male-Y Male-MA Male-O Female-Y Female-MA Female-O 4 h 0.087 0.078 0.081 0.087 0.084 0.082 0.084 0.077 0.071 0.067 0.058 0.056 0.067 0.068 0.068 0.076 0.071 0.072 24 h 1.113 1.02 0.868 0.762 0.745 0.741 0.804 0.729 0.685 0.84 0.814 0.725 0.643 0.67 0.682 0.664 0.663 0.658Figure 3B E. coli M_Y M_MA M_O F_Y F_MA F_O 1 h 0.337 0.308 0.299 0.308 0.288 0.299 0.256 0.266 0.254 0.226 0.229 0.222 0.216 0.209 0.194 0.223 0.224 0.220 4 h 0.931 1.022 1.050 0.949 0.962 0.913 0.792 0.795 0.754 0.843 0.790 0.818 0.681 0.794 0.775 0.678 0.724 0.668 S. aureus M_Y M_MA M_O F_Y F_MA F_O 1 h 0.23 0.23 0.23 0.22 0.22 0.22 0.22 0.22 0.22 0.24 0.21 0.23 0.24 0.23 0.23 0.22 0.22 0.22 4 h 1.05 1.06 0.88 0.71 0.75 0.66 0.7 0.73 0.65 0.84 0.73 0.75 0.75 0.75 0.69 0.54 0.57 0.54 Zymosan M_Y M_MA M_O F_Y F_MA F_O 1 h 0.67 0.65 0.66 0.72 0.72 0.74 0.63 0.63 0.59 0.53 0.53 0.58 0.53 0.51 0.47 0.5 0.48 0.48 4 h 1.04 0.95 1.01 1.04 1.05 0.99 0.84 0.83 0.83 0.66 0.64 0.63 0.69 0.69 0.63 0.68 0.76 0.67Figure 4 Old-Male Old-Female S-COOH 19.4 17.9 17.4 16.6 19.7 24.7 M-COOH 23.0 26.1 27.6 13.9 15.0 20.7 M-NH2 19.6 27.1 31.5 16.3 16.4 17.0 L-COOH 50.9 53.4 52.8 56.5 50.3 54.7 E. coli 26.4 25.9 32.7 20.9 13.2 22.7 S. aureus 29.8 26.8 34.8 30.1 26.3 30.1 Zymosan 16.0 17.0 17.0 -5.8 -18.2 -4.2Figure 5A y-axis x-axis x-axis x-axis x-axis FA FY MA MY -13.7735 9.629136 -25.6624 -5.56558 -18.7538 23.92111 -8.0031 8.552257 -15.1699 -8.77452 -24.3603 0.869651 -19.1581 -1.30142 -23.4823 -11.8133 -29.0012 16.71133 30.34387 19.42096 24.13154 21.73563 26.03056 17.01247 26.07154 -4.58089 26.17238 -8.50718 -0.62053 -19.5825 10.78328 -31.3192 8.791642 -4.43388 13.83544 -6.43518 11.82502 -15.5389Figure 5G YM OM YF OF 31.9 6.5 50.8 13.8 37.1 11.9 54.7 17.1 36.4 13.1 63.2 19.1 36.7 15.3 42.3 14.2 31.8 5.6 47.8 21.1Figure 6A size S-COOH without Young-Male Old-Male Young-Female Old-Female 38 62 56 57 54 38 61 54 56 57 37 61 59 52 55 M-COOH without Young-Male Old-Male Young-Female Old-Female 291 334 333 345 338 292 327 314 329 333 287 303 330 341 300Figure 6B uptake S-COOH without Young-Male Old-Male Young-Female Old-Female 0.97 0.96 0.91 0.86 0.91 1.06 1.02 0.98 0.89 0.92 0.97 1.05 1.00 0.87 0.93 M-COOH without Young-Male Old-Male Young-Female Old-Female 0.94 1.93 2.06 1.77 1.51 1.00 1.90 2.22 1.28 1.75 1.06 1.87 1.81 1.15 1.64__MACOSX/STAM-2025-0435_data/._STAM-2025-0435.xlsxSTAM-2025-0435_data/readme.txtsoftware: Microsoft Excel__MACOSX/STAM-2025-0435_data/._readme.txt