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[[Vol. 60]New Solid Materials Enable Broader Application of Medical Gases_ WPI-MANA.pdf](https://mdr.nims.go.jp/filesets/94629d25-860e-4504-aca8-e6b1f92e3b83/download)

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International Center for Materials Nanoarchitectonics (WPI-MANA)

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[[Research Highlights Vol.60] New Solid Materials Enable Broader Application of Medical Gases](https://mdr.nims.go.jp/datasets/4ad9f7c9-a24c-4e8d-a90f-806fa6dd40b6)

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2022/03/31 16:22 New Solid Materials Enable Broader Application of Medical Gases| MANAhttps://www.nims.go.jp/mana/research/highlights/vol60.html 1/3Previous  Index  NextResearch Highlights[Vol. 60]New Solid Materials Enable Broader Application of Medical Gases24 Aug, 2020Hydrogen sulfide (H2S) and nitric oxide (NO) are gases with useful bio-activities, suchas anti-oxidation, anti-inflammation and vasodilation. H2S is an ingredient in hot springand long known to have positive effects on the skin and cardiovascular system. NO is aselective and fast-acting pulmonary vasodilator, and is used in hospital intensive careunits to treat severe respiratory distress, including the so-called “blue-baby syndrome,”a life-threatening condition caused by pulmonary hypertension. In addition, the inhaledNO therapy is currently under clinical trials for COVID-19 infection.However, the application of these gases is limited since they are toxic at high concentrations andneed cumbersome high-pressure gas cylinders. For example, inhaled NO is an advanced medicaltreatment requiring expensive medical instruments and a trained operator to control and monitorthe purity and dose of the NO.To address these issues, a MANA research team of Shinsuke Ishihara and Nobuo Iyi has developedsolid materials that slowly and autonomously release small amounts of H2S and NO when theycontact with CO2 in air. The materials are based on layered double hydroxide (LDH), a clayhttps://www.nims.go.jp/mana/research/highlights/vol59.htmlhttps://www.nims.go.jp/mana/research/highlights/index.htmlhttps://www.nims.go.jp/mana/research/highlights/vol61.html2022/03/31 16:22 New Solid Materials Enable Broader Application of Medical Gases| MANAhttps://www.nims.go.jp/mana/research/highlights/vol60.html 2/3mineral, which incorporates gas source anions (HS− or NO2−). The materials exchange anions withCO2 and release H2S and NO.The concentration and duration of gas release are controllable by adjusting various factors, such ascomposition of materials, diffusion of gas molecules and anions, and chemical equilibrium.The team’s low-cost and safe-to-handle materials could be used to create a disposable medicalsystem for controlled release of bio-active gases under ambient air. Actually, the teamdemonstrated the potential utility of new gas-release system by creating a portable, hand-operated (and therefore battery-free) respirator that can supply therapeutically useful quantities ofNO into inhaled air.The work shows that LDH is an attractive material for gas release, and the CO2-driven system ispotentially useful for expanding opportunities of utilizing functional gases in a variety ofapplications.This research was carried out by Shinsuke Ishihara (Principal Researcher, Frontier MoleculesGroup) and Nobuo Iyi (Special Researcher, Soft Chemistry Group).Reference“Controlled Release of H2S and NO Gases Through CO2-Stimulated Anion Exchange”Shinsuke Ishihara and Nobuo IyiJournal : Nature Communications [January 23, 2020]DOI : 10.1038/s41467-019-14270-3(Press release on this research)"Development of a Solid Material Capable of Slowly Releasing H2S and NO” (24 January 2020)https://www.nims.go.jp/mana/news_room/press/2020012401.html（MANA E-BULLETIN）https://www.nims.go.jp/mana/ebulletin/AffiliationsInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for MaterialsScience (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, JapanContact informationInternational Center for Materials Nanoarchitectonics(WPI-MANA)National Institute for Materials Science1-1 Namiki, Tsukuba, Ibaraki 305-0044 JapanPhone: +81-29-860-4710E-mail: mana-pr[AT]ml.nims.go.jphttps://samurai.nims.go.jp/profiles/ishihara_shinsuke?locale=enhttps://samurai.nims.go.jp/profiles/iyi_nobuohttps://samurai.nims.go.jp/profiles/ishihara_shinsuke?locale=enhttps://samurai.nims.go.jp/profiles/iyi_nobuo?locale=enhttps://doi.org/10.1038/s41467-019-14270-3https://www.nims.go.jp/mana/news_room/press/2020012401.htmlhttps://www.nims.go.jp/mana/ebulletin/2022/03/31 16:22 New Solid Materials Enable Broader Application of Medical Gases| MANAhttps://www.nims.go.jp/mana/research/highlights/vol60.html 3/3