# Fileset

[[Vol. 7]Smart anticancer nanofibers_ Setting treatments to work together_ WPI-MANA.pdf](https://mdr.nims.go.jp/filesets/0184f6a7-026f-4b49-8a99-871203a05992/download)

## Creator

International Center for Materials Nanoarchitectonics (WPI-MANA)

## Rights

In Copyright[In Copyright](http://rightsstatements.org/vocab/InC/1.0/)

## Other metadata

[[Research Highlights Vol.7] Smart anticancer nanofibers: Setting treatments to work together](https://mdr.nims.go.jp/datasets/8a9968ea-18d6-42e3-9a97-c9cc8c81dec6)

## Fulltext

2022/04/04 10:27 Smart anticancer nanofibers: Setting treatments to work together| MANAhttps://www.nims.go.jp/mana/research/highlights/vol7.html 1/2Previous  Index  NextResearch Highlights[Vol. 7]Smart anticancer nanofibers: Setting treatments to work together12 Jul, 2013Incorporating magnetic nanoparticles and an anticancer drug intocrosslinked polymer nanofibers presents a twofold treatment for fightingcancer with diminished side effects.Figure 1. Design concept for a smart hyperthermia nanofiber system that usesmagnetic nanoparticles (MNPs) dispersed in temperature-responsive polymers.Anticancer drug, doxorubicin (DOX), is also incorporated into the nanofibers. Thenanofibers are chemically crosslinked. First, the device signal (alternatingmagnetic field, AMF) is turned 'on' to activate the MNPs in the nanofi bers. Then,the MNPs generate heat to collapse the polymer networks in the nanofiber,allowing the 'on-off' release of DOX. Both the generated heat and released DOXinduce apoptosis of cancer cells by hyperthermic and chemotherapeutic effects,respectively.Stimuli-responsive or ‘smart’ polymeric nanofibers have attracted increasing attention. Thenanoscale structures give rise to high sensitivity to stimuli while they can also be manipulatedeasily as macroscopic materials. Now researchers at International Center for MaterialsNanoarchitectonics (MANA) in Japan have demonstrated how they can be used to host magneticnanoparticles to exploit hyperthermal effects for treating cancer while avoiding the usual side-effects. The incorporation of doxorubicin in the nanofibers as well allows controlled release of theanticancer drug as an additional mechanism for killing cancer cells.Magnetic nanoparticles can kill cancer cells through the heat generated by induction whensubjected to an alternating magnetic field. Such hyperthermal treatments have also been shown tohttps://www.nims.go.jp/mana/research/highlights/vol6.htmlhttps://www.nims.go.jp/mana/research/highlights/index.htmlhttps://www.nims.go.jp/mana/research/highlights/vol8.html2022/04/04 10:27 Smart anticancer nanofibers: Setting treatments to work together| MANAhttps://www.nims.go.jp/mana/research/highlights/vol7.html 2/2improve the efficacy of anticancer drugs. However the nanoparticles can also lead to impairedmitochondrial function, inflammation, and DNA damage. Incorporating the nanoparticles intonanofibers may provide a solution.Young-Jin Kim , Mitsuhiro Ebara , and Takao Aoyagi electrspun the fibers from a solution of thepolymer poly(NIPAAm- co -HMAAm) mixed with a solution of magnetic nanoparticles anddoxorubicin. The heating caused by the nanoparticles when switching on an alternating magneticfield caused hyperthermal effects, as well as reversible deswelling and deformation of the fibers,which released the drug molecules. Investigations in vitro and in cell lines demonstrated effectivekilling of cancer cells, which was greatly reduced for hyperthermal treatments alone in the absenceof doxorubicin.As the authors point out “The doxorubicin/magnetic-nanoparticles nanofi ber induced the apoptosisof cancer cells due to a synergistic effect of chemotherapy and hyperthermia.” The workdemonstrates how smart nanofibers have potential for use as a manipulative material thatcombines hyperthermia and drug release treatments that can be controlled with the simpleswitching on or off of an alternating magnetic field.Reference"A smart hyperthermia nanofi ber with switchable drug release for inducing cancer apoptosis"Young-Jin Kim, Mitsuhiro Ebara, and Takao AoyagiJournal : Adv. Funct. Mater 23,46, 5753-5761 (2013)DOI : 10.1002/adfm.201300746AffiliationsInternational Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for MaterialsScience (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, JapanContact informationInternational Center for Materials Nanoarchitectonics(WPI-MANA)National Institute for Materials Science1-1 Namiki, Tsukuba, Ibaraki 305-0044 JapanPhone: +81-29-860-4710E-mail: mana-pr[AT]ml.nims.go.jphttps://onlinelibrary.wiley.com/doi/10.1002/adfm.201300746