# Influence of Pore Size of Mesoporous Silica on Physical Stability of Overloaded Celecoxib Glass

https://mdr.nims.go.jp/datasets/ff5f5d50-ab00-4159-b75a-6fcdcca8d7c2

## File

- [2025MolPharm_CEL_MS.pdf](https://mdr.nims.go.jp/filesets/a5d204d4-925f-4b06-a130-566e8e41b747/download) ([Detail](https://mdr.nims.go.jp/filesets/a5d204d4-925f-4b06-a130-566e8e41b747.md))

## Id

ff5f5d50-ab00-4159-b75a-6fcdcca8d7c2

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-11-09T18:48:18.894919Z

## Updated at

2025-11-10T03:30:15.153725Z

## Published at

2025-11-10T03:24:34.308156Z

## Doi



## First published url

https://doi.org/10.1021/acs.molpharmaceut.4c01482

## Date published

2025-05-05

## Recorded date published

2025-5-5

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Influence of Pore Size of Mesoporous Silica on Physical Stability of Overloaded
    Celecoxib Glass
  title_type: original
  lang: en

## Description

- description: 'The stabilization mechanism of mesoporous silica (MS) of two different
    pore sizes (21 and 2.5 nm) on overloaded celecoxib (CEL) glass was investigated.
    Differential scanning calorimetry (DSC) measurements revealed the presence of
    three fractions with different molecular mobilities: free, intermediate, and rigid
    ones. The free fraction exhibited cold crystallization during DSC heating and
    was assumed to have almost the same properties as those of the bulk molecules.
    The rigid fraction did not exhibit either glass transition or cold crystallization
    behavior, which should be stabilized by interactions with the MS surface. The
    remaining molecules exhibited glass transition behavior without any tendency toward
    cold crystallization during heating, which is called the intermediate fraction.
    The molecular dynamics of each fraction was investigated by using broadband dielectric
    spectroscopy (BDS).'
  description_type: abstract
  lang: und

## Creator

- name: Xue Han
  role: author
  orcid: https://orcid.org/0000-0003-4812-1410
  organization: National Institute for Materials Science
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: glass
  schema: not_defined
- subject: mesoporous silica
  schema: not_defined
- subject: crystallization
  schema: not_defined
- subject: cooperatively rearranging region
  schema: not_defined
- subject: broadband dielectric spectroscopy
  schema: not_defined
- subject: differential scanning calorimetry
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Molecular Pharmaceutics
  issn: '15438392'
  volume: '22'
  issue: '5'
  start_page: 2556
  end_page: 2567

## Conference



## Related item



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## Instrument



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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: a5d204d4-925f-4b06-a130-566e8e41b747
  filename: 2025MolPharm_CEL_MS.pdf
  content_type: application/pdf
  size: 4252803
  md5: 210afdfdf7183ef71c8bac8e0b01cd3a

## Thumbnail

fileset_id: a5d204d4-925f-4b06-a130-566e8e41b747
filename: 2025MolPharm_CEL_MS.pdf