# Harnessing DNA and Energy Cargo: Unveiling the Active Biogenesis and Applications of Bacterial Extracellular Vesicles

https://mdr.nims.go.jp/datasets/fce917e7-509f-42d8-808f-62f58c882510

## File

- [MDR_BookChapterBEV_takano (3)_oa.docx](https://mdr.nims.go.jp/filesets/22f231a2-0763-4c15-be7e-6eed7fb9a866/download) ([Detail](https://mdr.nims.go.jp/filesets/22f231a2-0763-4c15-be7e-6eed7fb9a866.md))

## Id

fce917e7-509f-42d8-808f-62f58c882510

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-01-18T23:00:34.986084Z

## Updated at

2026-01-19T01:38:01.272561Z

## Published at

2026-01-19T03:21:50.644799Z

## Doi

https://doi.org/10.48505/nims.6143

## First published url

https://doi.org/10.1007/978-981-97-7067-0_9

## Date published

2025-02-28

## Recorded date published

2025

## Resource type

book

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Harnessing DNA and Energy Cargo: Unveiling the Active Biogenesis and Applications
    of Bacterial Extracellular Vesicles'
  title_type: original
  lang: en

## Description

- description: "Human microbiota, akin to human cells releasing exosomes, produce
    spherical biological nanoparticles, bacterial extracellular vesicles (BEVs). These
    BEVs are composed of lipid bilayers and encapsulate a variety of biological molecules
    from their source cells such as signaling molecules, genetic materials, and proteins.
    BEVs have been known to contribute to diverse biological processes in the human
    body by mediating both microbe-microbe and host-microbe interactions (Schwechheimer
    and Kuehn 2015; Cuesta et al. 2021). Yet, while the importance of their cargo
    is well-recognized, the question remains: do bacteria actively biosynthesize the
    BEVs to control their cargo on purpose?\r\nRecent studies have been demonstrated
    that BEVs are not just the by-products of cell-lysis or imbalance in local cell
    membrane properties but produced via various types of regulations (Fig. 1)(Schwechheimer
    and Kuehn 2015). Genetic alterations can either enhance or inhibit the formation
    of BEVs (Kitagawa et al. 2010; Kulp et al. 2015), and evidence points to the selective,
    rather than random, packaging of certain molecules like proteins and lipids within
    BEVs (Schwechheimer and Kuehn 2015; Bonnington and Kuehn 2016; Orench-Rivera and
    Kuehn 2021; Naradasu et al. 2021)."
  description_type: abstract
  lang: eng

## Creator

- name: Sotaro Takano
  role: author
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Electrochemical
    Nano-Bio Group
- name: Akihiro Okamoto
  role: author
  orcid: https://orcid.org/0000-0002-8102-4316
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Electrochemical
    Nano-Bio Group

## Contact agent



## Publisher

organization: Springer Singapore

## Managing organization



## Keyword

- subject: bacterial membrane vesicle
  schema: not_defined
- subject: single-particle analysis
  schema: not_defined
- subject: microbiome
  schema: not_defined
- subject: nanowire
  schema: not_defined

## Rights

- description: This ebook is designed with accessibility in mind, aiming to meet the
    ePub Accessibility 1.0 AA and WCAG 2.0 Level AA standards. Its features include
    described images and other non-text content, screenreader-friendly navigation
    and accessible math. Math is represented either as MathML, LaTeX or in images.
    If math is represented as image, Alt Text might not be present. We recognize the
    importance of accessibility, and we welcome queries about accessibility for any
    of our products. If you have a question or an access need, please get in touch
    with us at accessibilitysupport@springernature.com.
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Extracellular Fine Particles

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 22f231a2-0763-4c15-be7e-6eed7fb9a866
  filename: MDR_BookChapterBEV_takano (3)_oa.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 1730454
  md5: 4acabc2fc735b3e3a677468bf637280a

## Thumbnail

fileset_id: 22f231a2-0763-4c15-be7e-6eed7fb9a866
filename: MDR_BookChapterBEV_takano (3)_oa.docx