# Eutectic-Driven Recrystallization of Coamorphous Bicalutamide + Niclosamide Systems: Contrasting Stability above and below                    <i>T</i>                    <sub>g</sub>

https://mdr.nims.go.jp/datasets/fce8ac6a-36e0-4c1d-b3a7-7e58dc65a647

## File

- [2026MolPharm_BICNIC.pdf](https://mdr.nims.go.jp/filesets/a2ff2448-51d8-4e9e-92bf-8246aebdcd96/download) ([Detail](https://mdr.nims.go.jp/filesets/a2ff2448-51d8-4e9e-92bf-8246aebdcd96.md))

## Id

fce8ac6a-36e0-4c1d-b3a7-7e58dc65a647

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-08-19T04:02:37.596134Z

## Updated at

2026-08-19T04:05:59.499426Z

## Published at

2026-08-19T07:24:49.313666Z

## Doi



## First published url

https://doi.org/10.1021/acs.molpharmaceut.5c01958

## Date published

2026-07-06

## Recorded date published

2026-7-6

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: |-
    Eutectic-Driven Recrystallization of Coamorphous Bicalutamide + Niclosamide Systems: Contrasting Stability above and below
                        <i>T</i>
                        <sub>g</sub>
  title_type: original
  lang: en

## Description

- description: Coamorphization is a promising strategy to enhance the physical stability
    of poorly water-soluble drugs. However, the relationship between composition,
    molecular dynamics, and long-term stability remains insufficiently understood.
    Here, we investigate coamorphous  systems composed of bicalutamide (BIC) and niclosamide
    (NIC), focusing on how the eutectic composition defined in the crystalline state
    translate into molecular dynamics  and long-term physical stability of the corresponding
    amorphous systems above and below the glass transition temperature (Tg). Thermal
    analysis revealed a eutectic point in the close vicinity of 25 wt % NIC, enabling
    safe melt-based amorphization of NIC without thermal degradation. Broadband dielectric
    spectroscopy showed that the addition of NIC does not significantly affect the
    molecular mobility of amorphous BIC, as reflected by 85-92, as well as similar
    α-relaxation dynamics across all compositions. Despite these similarities, the
    physical stability of the coamorphous systems exhibits a pronounced composition
    dependence. Under accelerated conditions in the supercooled liquid state (T>Tg),
    the coamorphous system corresponding to the eutectic concentration displays the
    highest resistance to recrystallization, In contrast, long-term X-ray diffraction
    studies performed under glassy-state conditions (T<Tg) reveal a different stability
    ranking. These findings indicate that the stabilization observed for compositions
    corresponding to supercooled liquid and glassy state conditions.
  description_type: abstract
  lang: und

## Creator

- name: Paulina Poloczek
  role: author
- name: Justyna Knapik-Kowalczuk
  role: author
  orcid: https://orcid.org/0000-0003-3736-8098
- name: Joanna Klimontko
  role: author
- name: Xue Han
  role: author
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365
- name: Marian Paluch
  role: author
  orcid: https://orcid.org/0000-0002-7280-8557

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: eutectic
  schema: not_defined
- subject: crystallization
  schema: not_defined
- subject: broadband dielectric spectroscopy
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Molecular Pharmaceutics
  issn: '15438384'
  volume: '23'
  issue: '7'
  start_page: 3641
  end_page: 3653

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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



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## Fileset

- id: a2ff2448-51d8-4e9e-92bf-8246aebdcd96
  filename: 2026MolPharm_BICNIC.pdf
  content_type: application/pdf
  size: 4666058
  md5: b4d0b001dce687d99fc9fc34f3bbe73b

## Thumbnail

fileset_id: a2ff2448-51d8-4e9e-92bf-8246aebdcd96
filename: 2026MolPharm_BICNIC.pdf