# Initial bone tissue reactions of hydroxyapatite/collagen–(3‐glycidoxypropyl)trimethoxysilane injectable bone paste

https://mdr.nims.go.jp/datasets/fcd45a39-1cbe-4ad0-89ae-3976cc6513b4

## File

- [J Biomed Mater Res - 2024 - Sato - Initial bone tissue reactions of hydroxyapatite collagen  3‐glycidoxypropyl_Online published version.pdf](https://mdr.nims.go.jp/filesets/c258cb0d-321e-4b88-a50c-6329d4eb3d42/download) ([Detail](https://mdr.nims.go.jp/filesets/c258cb0d-321e-4b88-a50c-6329d4eb3d42.md))

## Id

fcd45a39-1cbe-4ad0-89ae-3976cc6513b4

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-30T07:35:57.177638Z

## Updated at

2024-09-02T07:30:11.568108Z

## Published at

2024-09-02T07:30:11.644201Z

## Doi



## First published url

https://doi.org/10.1002/jbm.b.35451

## Date published

2024-07-25

## Recorded date published

2024-8

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Initial bone tissue reactions of hydroxyapatite/collagen–(3‐glycidoxypropyl)trimethoxysilane
    injectable bone paste
  title_type: original
  lang: en

## Description

- description: We have previously reported that a novel bioresorbable self-setting
    injectable bone paste composed of hydroxyapatite/collagen bone-like nanocomposite
    (HAp/Col) and (3-glycidoxypropyl)trimethoxysilane (GPTMS) was successfully prepared
    and was replaced with new bone within 3 months of implantation in defects created
    in porcine tibia.  In this study, the HAp/Col-GPTMS paste was implanted into bone
    defects in rat tibiae to investigate the initial kinetics and bone tissue response.  Even
    though more than 35% of GPTMS molecules should be eluted rapidly from directly
    injected pastes according to previously reported cell culture tests, in this study,
    energy dispersive X-ray spectrometry did not detect Si (GPTMS) deposition in tissues
    surrounding the paste at one day post-implantation.  Further, no abnormal inflammatory
    responses were observed in the surrounding tissues over the test period for both
    directly injected and pre-hardened pastes.  Companying these observations with
    the results of the previous animal test (in which the paste was fully resorbed
    and was substituted with new bone), the eluted GPTMS resolved in no harm in vivo
    from the initial to final (completely resorbed) stages. Material resorption rates
    calculated from X-ray micro-computed tomography (µ-CT) images decreased with increasing
    in GPTMS concentration.  Histological observations indicated that tartrate-resistant
    acid phosphatase (TRAP) active cells, (assumed to be osteoclasts), exist on the
    periphery of pastes.  This result suggested that the paste was resorbed by osteoclasts
    in the same way as the HAp/Col.  Since a good correlation was observed between
    TRAP active areas in histological sections and material resorption rate calculated
    from µ-CT, the TRAP activity coverage ratio offers the possibility to estimate
    the osteoclastic resorption ratio of materials which are replaced with bone via
    bone remodeling process.
  description_type: abstract
  lang: und

## Creator

- name: Taira Sato
  role: author
- name: Yuki Shirosaki
  role: author
- name: Sho Oshima
  role: author
- name: Kanji Tsuru
  role: author
- name: Yoshihisa Koyama
  role: author
- name: Mamoru Aizawa
  role: author
- name: Masanori Kikuchi
  role: author
  orcid: https://orcid.org/0000-0002-9451-8147

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: "(3-glycidoxypropyl)trimethoxysilane"
  schema: not_defined
- subject: bioresorbability evaluation
  schema: not_defined
- subject: bone tissue reaction
  schema: not_defined
- subject: hydroxyapatite/collagen
  schema: not_defined
- subject: injectable bone paste
  schema: not_defined

## Rights

- description: This is an open access article under the terms of the Creative Commons
    Attribution-NonCommercial-NoDerivs License, which permits use and distribution
    in any medium, provided the original work is properly cited, the use is non-commercial
    and no modifications or adaptations are made.
  identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: 'Journal of Biomedical Materials Research Part B: Applied Biomaterials'
  issn: '15524973'
  volume: '112'
  issue: '8'
  article_number: e35451

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: c258cb0d-321e-4b88-a50c-6329d4eb3d42
  filename: J Biomed Mater Res - 2024 - Sato - Initial bone tissue reactions of hydroxyapatite
    collagen  3‐glycidoxypropyl_Online published version.pdf
  content_type: application/pdf
  size: 46732283
  md5: d26600913db8600e4034ed499025cad1

## Thumbnail

fileset_id: c258cb0d-321e-4b88-a50c-6329d4eb3d42
filename: J Biomed Mater Res - 2024 - Sato - Initial bone tissue reactions of hydroxyapatite
  collagen  3‐glycidoxypropyl_Online published version.pdf