# In Situ Forming Supramolecular Nanofiber Hydrogel as a Biodegradable Liquid Embolic Agent for Postembolization Tissue Remodeling

https://mdr.nims.go.jp/datasets/fb361833-2766-4463-bdc5-e0d9d86ca35c

## File

- [Manuscript.pdf](https://mdr.nims.go.jp/filesets/f95353da-c1fb-470c-80fa-bc4deaca1d10/download) ([Detail](https://mdr.nims.go.jp/filesets/f95353da-c1fb-470c-80fa-bc4deaca1d10.md))

## Id

fb361833-2766-4463-bdc5-e0d9d86ca35c

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-02-19T01:41:20.828680Z

## Updated at

2025-02-26T07:30:29.981013Z

## Published at

2025-02-26T07:30:30.119301Z

## Doi

https://doi.org/10.48505/nims.5346

## First published url

https://doi.org/10.1002/adhm.202403784

## Date published

2024-11-07

## Recorded date published

2025-2

## Resource type

journal_article

## Manuscript type

authors_original

## Collection



## Title

- title: In Situ Forming Supramolecular Nanofiber Hydrogel as a Biodegradable Liquid
    Embolic Agent for Postembolization Tissue Remodeling
  title_type: original
  lang: en

## Description

- description: Embolic agents have been widely used to treat blood vessel abnormalities
    in interventional radiology as a minimally invasive procedure. However, only a
    few biodegradable liquid embolic agents exhibit high embolization performance,
    biodegradability, and operability. Herein, we report the design of in situ-forming
    supramolecular nanofiber (SNF) hydrogels as biodegradable liquid embolic agents
    with the assistance of Bayesian optimization through an active learning pipeline.
    Chemically modified gelatin with hydrogen-bonding moieties produced fibrin-inspired
    nanofiber-based hydrogels with a high blood coagulation capacity. The low viscosity
    of the SNF hydrogels made them injectable using a microcatheter, and the hydrogel
    showed sufficient tissue adhesion to the blood vessel walls and very weak adhesion
    to the catheter tubes. Moreover, the SNF hydrogels exhibited high blood compatibility,
    cytocompatibility, cell-adhesive properties, and biodegradability (in vitro and
    in vivo). Intravascularly delivered SNF hydrogels induced embolization of rat
    femoral arteries. This biodegradable liquid embolic agent could be a powerful
    tool for interventional radiology in the treatment of various diseases, including
    aortic aneurysm stent grafting, gynecological diseases, and liver cancer.
  description_type: abstract
  lang: und

## Creator

- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Miho Ohta
  role: author
- name: Debabrata Palai
  role: author
  orcid: https://orcid.org/0000-0003-1192-6143
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Kensaku Mori
  role: author
- name: Ryotaro Akagi
  role: author
- name: Christophe Bajan
  role: author
  orcid: https://orcid.org/0009-0008-1433-9618
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Guillaume Lambard
  role: author
  orcid: https://orcid.org/0000-0003-0275-4079
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Keitaro Sodeyama
  role: author
  orcid: https://orcid.org/0000-0002-9228-0729
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Hydrogel
  schema: not_defined
- subject: Embolic agent
  schema: not_defined
- subject: Machine learning
  schema: not_defined

## Rights

- description: 'This is the pre-peer reviewed version of the following article: A.
    Nishiguchi, M. Ohta, D. Palai, S. Ito, K. Mori, R. Akagi, C. Bajan, G. Lambard,
    K. Sodeyama, T. Taguchi, In Situ Forming Supramolecular Nanofiber Hydrogel as
    a Biodegradable Liquid Embolic Agent for Postembolization Tissue Remodeling. Adv.
    Healthcare Mater. 2025, 14, 2403784, which has been published in final form at
    https://doi.org/10.1002/adhm.202403784. This article may be used for non-commercial
    purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived
    Versions.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

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## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced Healthcare Materials
  issn: '21922659'
  volume: '14'
  issue: '4'
  article_number: '2403784'

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## Funding

- funder_name: Uehara Memorial Foundation
- funder_name: Inamori Foundation
- identifier: 22H03962
  funder_name: Japan Society for the Promotion of Science
- identifier: 23H01718
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: f95353da-c1fb-470c-80fa-bc4deaca1d10
  filename: Manuscript.pdf
  content_type: application/pdf
  size: 1485300
  md5: 1cb265c26ad7bde03e880b7a9a55cec5

## Thumbnail

fileset_id: f95353da-c1fb-470c-80fa-bc4deaca1d10
filename: Manuscript.pdf