# Biochemical state in tissue can be detected through ultrasound signal

https://mdr.nims.go.jp/datasets/fb1edc9a-34b1-44c7-bb23-62511c5edd65

## File

- [s44385-025-00026-w.pdf](https://mdr.nims.go.jp/filesets/27993413-a1cb-4c45-a300-ad10bedbf7bb/download) ([Detail](https://mdr.nims.go.jp/filesets/27993413-a1cb-4c45-a300-ad10bedbf7bb.md))

## Id

fb1edc9a-34b1-44c7-bb23-62511c5edd65

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-06-13T07:52:00.828014Z

## Updated at

2025-06-17T23:30:18.894974Z

## Published at

2025-06-17T23:18:55.182887Z

## Doi



## First published url

https://doi.org/10.1038/s44385-025-00026-w

## Date published

2025-06-13

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Biochemical state in tissue can be detected through ultrasound signal
  title_type: original
  lang: en

## Description

- description: 超音波イメージングを用いて、15日間にわたるがんスフェロイド内部の動態を非侵襲的に評価できることを実証した。散乱に基づく音響パラメータを用いることで、細胞増殖、アポトーシス、壊死に対応する明度および密度の空間的変化を明らかにした。従来の光学イメージング技術は浸透深度の制限や光毒性の影響を受けやすいが、超音波イメージングにより、細胞動態や治療反応の評価に新たな知見をもたらすことが期待される。
  description_type: abstract
  lang: eng
- description: We demonstrated that the internal dynamics of cancer spheroids over
    a 15-day period can be non-invasively evaluated using ultrasound imaging. By employing
    scattering-based acoustic parameters, we revealed spatial variations in brightness
    and density that correlate with cell proliferation, apoptosis, and necrosis. While
    conventional optical imaging techniques are limited by penetration depth and phototoxicity,
    ultrasound imaging offers new insights into cellular dynamics and therapeutic
    responses.
  description_type: abstract
  lang: en
- description: 超音波イメージングを用いて、15日間にわたるがんスフェロイド内部の動態を非侵襲的に評価できることを実証した。散乱に基づく音響パラメータを用いることで、細胞増殖、アポトーシス、壊死に対応する明度および密度の空間的変化を明らかにした。従来の光学イメージング技術は浸透深度の制限や光毒性の影響を受けやすいが、超音波イメージングにより、細胞動態や治療反応の評価に新たな知見をもたらすことが期待される。
  description_type: abstract
  lang: eng
- description: We demonstrated that the internal dynamics of cancer spheroids over
    a 15-day period can be non-invasively evaluated using ultrasound imaging. By employing
    scattering-based acoustic parameters, we revealed spatial variations in brightness
    and density that correlate with cell proliferation, apoptosis, and necrosis. While
    conventional optical imaging techniques are limited by penetration depth and phototoxicity,
    ultrasound imaging offers new insights into cellular dynamics and therapeutic
    responses.
  description_type: abstract
  lang: en

## Creator

- name: Kazuyo Ito
  role: author
  organization: Tokyo University of Agriculture and Technology
- name: Yuta Iijima
  role: author
  organization: Tokyo University of Agriculture and Technology
- name: Tomoki Misumi
  role: author
  organization: Tokyo University of Agriculture and Technology
- name: Gen Hayase
  role: author
  orcid: https://orcid.org/0000-0003-1970-6129
  organization: National Institute for Materials Science
  department: Research Center for Electronic and Optical Materials/Functional Materials
    Field/Amorphous Material Group
- name: Kazuki Tamura
  role: author
  organization: Hamamatsu University School of Medicine
- name: Kenji Ikushima
  role: author
  organization: Tokyo University of Agriculture and Technology
- name: Daisuke Yoshino
  role: author
  organization: Tokyo University of Agriculture and Technology

## Contact agent



## Publisher

organization: 'Springer Nature '

## Managing organization



## Keyword

- subject: ultrasound
  schema: not_defined
- subject: cancer imaging
  schema: not_defined
- subject: spheroid
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: npj Biomedical Innovations
  issn: '30051444'
  volume: '2'
  issue: '1'
  article_number: '18'

## Conference



## Related item



## Funding

- identifier: KAKENHI No. 21K19893
  funder_name: JSPS
  description: 超高速ブロックビルド法の確立による臓器オルガノイドの実スケール化への挑戦
- funder_name: Nakatani Foundation for Advancement of Measuring Technologies in Biomedical
    Engineering
- funder_name: Terumo Life Science Foundation

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## Fileset

- id: 27993413-a1cb-4c45-a300-ad10bedbf7bb
  filename: s44385-025-00026-w.pdf
  content_type: application/pdf
  size: 5509976
  md5: 13aed62c84c4e29b39c67b01e6dc8a64

## Thumbnail

fileset_id: 27993413-a1cb-4c45-a300-ad10bedbf7bb
filename: s44385-025-00026-w.pdf