# Synergistic effects of metal-organic nanoplatform and guanine quadruplex-based CpG oligodeoxynuceotides in therapeutic cancer vaccines with different tumor antigens

https://mdr.nims.go.jp/datasets/f994a103-badb-44a0-9672-4cf357b3a6b8

## File

- [2024 Vaccines -Xia Li.pdf](https://mdr.nims.go.jp/filesets/517f3129-1472-465c-b9e9-43f92eae1144/download) ([Detail](https://mdr.nims.go.jp/filesets/517f3129-1472-465c-b9e9-43f92eae1144.md))

## Id

f994a103-badb-44a0-9672-4cf357b3a6b8

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-06-27T07:29:00.119816Z

## Updated at

2024-06-27T23:30:16.459924Z

## Published at

2024-06-27T23:30:16.556915Z

## Doi



## First published url

https://doi.org/10.3390/vaccines12060649

## Date published

2024-06-11

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Synergistic effects of metal-organic nanoplatform and guanine quadruplex-based
    CpG oligodeoxynuceotides in therapeutic cancer vaccines with different tumor antigens
  title_type: original
  lang: en

## Description

- description: Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanosine
    (CpG) motifs are readily recognized by Toll-like receptor 9 on immune cells, trigger
    an immunomodulatory cascade, induce a Th1 -biased immune milieu and have a great
    potential as an adjuvant in cancer vaccines. In this study, a green one-step synthesis
    process was adopted to prepare amino-rich metal-organic nanoplatform (FN). The
    synthesized FN nanoplatform can simultaneously and ef-fectively load model tumor
    antigens (OVA) / autologous tumor antigens (dLLC) and im-munostimulatory CpG ODNs
    with an unmodified PD backbone and guanine-quadruplex structure to obtain various
    cancer vaccines. The FN nanoplatform and immunostimulatory CpG ODNs generate synergistic
    effects to enhance the immunogenicity of different antigens and inhibit the growth
    of established and distant tumors in both the murine E.G7-OVA lymphoma model and
    the murine Lewis lung carcinoma model. In E.G7-OVA lymphoma model, vaccination
    efficiently in-crease the CD4+, CD8+ and tetramer+CD8+ T cell populations in the
    spleens. In Lewis lung carci-noma model, vaccination efficiently increase the
    CD3+CD4+ and CD3+CD8+ T cell populations in the spleens and CD3+CD8+, CD3-CD8+
    and CD11b+CD80+ cell populations in the tumors, suggesting the alteration of tumor
    microenvironment from cold to hot tumors.
  description_type: abstract
  lang: eng

## Creator

- name: Xia Li
  role: author
  orcid: https://orcid.org/0000-0002-3246-4462
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart
    Polymers Group
  ror: https://ror.org/026v1ze26
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart
    Polymers Group
  ror: https://ror.org/026v1ze26
- name: Naoto Shirahata
  role: author
  orcid: https://orcid.org/0000-0002-1217-7589
  organization: National Institute for Materials Science
  department: Research Center for Materials Nanoarchitectonics (MANA)/Nanomaterials
    Field/Nanoparticle Group
  ror: https://ror.org/026v1ze26
- name: Tomohiko Yamazaki
  role: author
  orcid: https://orcid.org/0000-0003-2136-8042
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Medical
    Soft Matter Group
  ror: https://ror.org/026v1ze26
- name: Nobutaka Hanagata
  role: author
  orcid: https://orcid.org/0000-0001-6079-3426
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Multidisciplinary Digital Publishing Institute (MDPI)

## Managing organization



## Keyword

- subject: TLR9 agonist
  schema: not_defined
- subject: CpG oligodeoxynucleotides
  schema: not_defined
- subject: nanoplatform
  schema: not_defined
- subject: cancer vaccines
  schema: not_defined
- subject: adjuvant
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Vaccines
  issn: 2076393X
  volume: '12'
  issue: '6'
  article_number: '649'

## Conference



## Related item



## Funding

- identifier: 23K04555 and 22K20517
  funder_name: KAKENHI
- funder_name: Takeda Science Foundation

## Instrument



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## Chemical composition



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## Fileset

- id: 517f3129-1472-465c-b9e9-43f92eae1144
  filename: 2024 Vaccines -Xia Li.pdf
  content_type: application/pdf
  size: 5371136
  md5: e4fa0d5395d91c88a58a777a58135851

## Thumbnail

fileset_id: 517f3129-1472-465c-b9e9-43f92eae1144
filename: 2024 Vaccines -Xia Li.pdf