# Characterization and evaluation of the ability of graphene quantum dots to affect α-synuclein aggregation in synucleinopathy models

https://mdr.nims.go.jp/datasets/f7762a68-fb4b-4bec-9d72-55bf39c48627

## File

- [Characterization and evaluation of the ability of graphene quantum dots to affect  -synuclein aggregation in synucleinopathy models.pdf](https://mdr.nims.go.jp/filesets/36a2fbed-4fdf-40f3-9d35-e6297af0a62c/download) ([Detail](https://mdr.nims.go.jp/filesets/36a2fbed-4fdf-40f3-9d35-e6297af0a62c.md))
- [STAM-2026-0043_data.zip](https://mdr.nims.go.jp/filesets/db8d9645-66c8-4311-9d09-6954c6b262cd/download) ([Detail](https://mdr.nims.go.jp/filesets/db8d9645-66c8-4311-9d09-6954c6b262cd.md))

## Id

f7762a68-fb4b-4bec-9d72-55bf39c48627

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-05-14T02:05:30.137817Z

## Updated at

2026-05-21T02:41:20.557479Z

## Published at

2026-05-21T05:27:40.081815Z

## Doi

https://doi.org/10.48505/nims.6305

## First published url

https://doi.org/10.1080/14686996.2026.2662693

## Date published

2026-12-31

## Recorded date published

2026-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Characterization and evaluation of the ability of graphene quantum dots to
    affect α-synuclein aggregation in synucleinopathy models
  title_type: original
  lang: en

## Description

- description: Synucleinopathies, including Parkinson’s disease and multiple system
    atrophy (MSA), are neurodegenerative disorders characterized by aggregation of
    α-synuclein (ASN). Nanomaterials capable of modulating protein misfolding represent
    a potential intervention strategy. Here, we synthesized graphene quantum dots
    (GQDs) and systematically evaluated their physicochemical properties and biological
    activity against ASN aggregation. The GQDs were characterized using spectroscopic,
    electron microscopy, and colloidal techniques to determine surface chemistry,
    charge, optical properties, and crystalline structure. Biological evaluation demonstrated
    cytocompatibility in human dermal fibroblasts (IC50 = 90 µg mL−1 at 24 h) with
    assessments of DNA damage and inflammatory responses. Functionally, GQDs destabilized
    preformed ASN fibrils in a cell-free assay, as evidenced by reduced Thioflavin-T
    fluorescence. In primary murine dopaminergic neurons, GQDs decrease pS129-ASN
    inclusion formation without compromising neuronal viability. Most importantly,
    intranasal administration of GQDs in an MSA mouse model reduced ASN immunoreactivity
    in the brain. Collectively, our data indicate that the synthetized GQDs are bioactive
    and can modulate ASN aggregation across cell-free, neuronal, and in vivo models.
    Importantly, physicochemical properties govern nano – bio interactions, providing
    a rationale for further refinement of GQDs as a biomaterial platform for synucleinopathy-related
    applications.
  description_type: abstract
  lang: en

## Creator

- name: Tuba Oz
  role: author
  organization: Poznan University of Medical Sciences
  department: a Department of Toxicology
- name: Anna Alwani
  role: author
- name: Agnieszka Kamińska
  role: author
- name: Barbara Jachimska
  role: author
- name: Makoto Timmon Tanaka
  role: author
- name: Yasuo Miki
  role: author
- name: Koichi Wakabayashi
  role: author
- name: Katarzyna Maziarz
  role: author
- name: Sheetal Kaushik Bhardwaj
  role: author
- name: Ajeet Kaushik
  role: author
- name: Małgorzata Figiel
  role: author
- name: Piotr Chmielarz
  role: author
- name: Małgorzata Kujawska
  role: author

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Graphene quantum dots
  schema: not_defined
- subject: bioactive nanomaterials
  schema: not_defined
- subject: Nano–bio interactions
  schema: not_defined
- subject: amyloid inhibition
  schema: not_defined
- subject: nanotoxicology
  schema: not_defined
- subject: cytocompatibility
  schema: not_defined
- subject: nano–bio interface
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '27'
  issue: '1'
  article_number: '2662693'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 36a2fbed-4fdf-40f3-9d35-e6297af0a62c
  filename: Characterization and evaluation of the ability of graphene quantum dots
    to affect  -synuclein aggregation in synucleinopathy models.pdf
  content_type: application/pdf
  size: 7601307
  md5: 3ce9bdc64567055323c228cf38928404
- id: db8d9645-66c8-4311-9d09-6954c6b262cd
  filename: STAM-2026-0043_data.zip
  content_type: application/zip
  size: 15734350
  md5: 95a5fa6fbe2f8dbd44abfaa4634b5185

## Thumbnail

fileset_id: 36a2fbed-4fdf-40f3-9d35-e6297af0a62c
filename: Characterization and evaluation of the ability of graphene quantum dots
  to affect  -synuclein aggregation in synucleinopathy models.pdf