# Toward the Era of Visualizing Chemical Reactions : Cinematic Chemistry Enabled by High-Speed Atomic-Resolution Electron Microscopy

https://mdr.nims.go.jp/datasets/f4306c01-7a71-4144-b7ad-37e7c62ed6de

## File

- [Toshiki Shimizu_MS_revised_nologo.pdf](https://mdr.nims.go.jp/filesets/d3159fef-a35a-49dd-9d23-aa3acaab3d60/download) ([Detail](https://mdr.nims.go.jp/filesets/d3159fef-a35a-49dd-9d23-aa3acaab3d60.md))

## Id

f4306c01-7a71-4144-b7ad-37e7c62ed6de

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-08-19T05:25:09.192360Z

## Updated at

2025-08-19T23:30:27.572785Z

## Published at

2025-08-19T23:24:24.061313Z

## Doi

https://doi.org/10.48505/nims.5642

## First published url

https://doi.org/10.1380/vss.68.442

## Date published

2025-08-10

## Recorded date published

2025

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Toward the Era of Visualizing Chemical Reactions : Cinematic Chemistry Enabled
    by High-Speed Atomic-Resolution Electron Microscopy'
  title_type: original
  lang: en

## Description

- description: This study presents a real-time atomic-resolution observation of chemical
    reaction dynamics at the single-molecule level using single-molecule atomic-resolution
    time-resolved electron microscopy (SMART-EM). [60]Fullerene (C60) molecules were
    encapsulated in carbon nanotubes and monitored at 1600 frames per second using
    a direct electron detection (DED) camera. To overcome the inherently low signal-to-noise
    ratio in such ultrafast imaging, we applied Chambolle total variation denoising,
    enabling clear visualization of single-frame structures. This allowed us to resolve
    a cascade reaction featuring multiple transient intermediates, including a highly
    strained, short-lived species (＜3 ms). Structural identification was achieved
    via cross-correlation image matching analysis with simulated TEM images based
    on Osawa-Tomanek models. Even fleeting high-energy states were experimentally
    captured, validating theoretical predictions and revealing the stochastic nature
    of molecular trajectories. This work establishes a new paradigm for visualizing
    molecular dynamics, highlighting the emerging field of “cinematic chemistry.”
  description_type: abstract
  lang: und

## Creator

- name: Toshiki SHIMIZU
  role: author
- name: Koji HARANO
  role: author
  orcid: https://orcid.org/0000-0001-6800-8023
- name: Eiichi NAKAMURA
  role: author

## Contact agent



## Publisher

organization: Surface Science Society Japan

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## Keyword

- subject: 電子顕微鏡
  schema: not_defined
- subject: 単分子観察
  schema: not_defined
- subject: 化学反応
  schema: not_defined
- subject: その場観察
  schema: not_defined
- subject: 映像分子科学
  schema: not_defined

## Rights

- description: "©日本表面真空学会"
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Vacuum and Surface Science
  issn: '24335835'
  volume: '68'
  issue: '8'
  start_page: 442
  end_page: 447
  article_number: '20181533'

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## Fileset

- id: d3159fef-a35a-49dd-9d23-aa3acaab3d60
  filename: Toshiki Shimizu_MS_revised_nologo.pdf
  content_type: application/pdf
  size: 2288285
  md5: 3610efac9104e669da2e01c70871af22

## Thumbnail

fileset_id: d3159fef-a35a-49dd-9d23-aa3acaab3d60
filename: Toshiki Shimizu_MS_revised_nologo.pdf