# Isoconversional kinetic analysis of thermal decomposition of Bidirectionally stabilized amorphous formulation loading Vitamin D3 (Cholecalciferol) and Calcium Carbonate

https://mdr.nims.go.jp/datasets/f2249751-6772-41f4-afc5-2ef63a7b47b3

## File

- [ThermochimActa2024.docx](https://mdr.nims.go.jp/filesets/74d2af39-1177-4ead-a2a8-578a997d4600/download) ([Detail](https://mdr.nims.go.jp/filesets/74d2af39-1177-4ead-a2a8-578a997d4600.md))

## Id

f2249751-6772-41f4-afc5-2ef63a7b47b3

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-11T12:48:05.396957Z

## Updated at

2026-03-30T23:30:04.225896Z

## Published at

2026-03-30T23:15:42.946530Z

## Doi

https://doi.org/10.48505/nims.4675

## First published url

https://doi.org/10.1016/j.tca.2024.179740

## Date published

2024-03-30

## Recorded date published

2024-6

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Isoconversional kinetic analysis of thermal decomposition of Bidirectionally
    stabilized amorphous formulation loading Vitamin D3 (Cholecalciferol) and Calcium
    Carbonate
  title_type: original
  lang: en

## Description

- description: Cholecalciferol, generally known as vitamin D3 (VD), and calcium (Ca2+)
    are very common dietary co-supplements in the pharmaceutical formulations, as
    they are symbiotically and pharmacologically dependent. Development of the VD/Ca2+
    formulation is highly challenging due to stability and solubility issues, mainly
    for VD instability toward temperature, light, oxygen and pH. In this study, VD
    was loaded into carrier which consisted of amorphous calcium carbonate (ACC) and
    hydroxypropyl methylcellulose acetate succinate (HPMCAS), yielding amorphous VD/ACC/HPMCAS
    formulation with various composition ratios.
  description_type: abstract
  lang: und

## Creator

- name: Dijana Jelić
  role: author
- name: Miho Araki
  role: author
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: cholecalciferol
  schema: not_defined
- subject: amorphous calcium carbonate
  schema: not_defined
- subject: thermal stability
  schema: not_defined
- subject: isoconversional kinetics
  schema: not_defined

## Rights

- description: "© 2024. \r\nLicensed under the Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0/."
  identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-03-30
end_date: 2026-03-31

## Journal

- title: Thermochimica Acta
  issn: '00406031'
  volume: '736'
  article_number: '179740'

## Conference



## Related item



## Funding

- identifier: 23G05
  funder_name: Matsumae International Foundation
- identifier: 19.032/961-96/23
  funder_name: Ministry of Scientific and Technological Development, Higher Education
    and Information Society

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 74d2af39-1177-4ead-a2a8-578a997d4600
  filename: ThermochimActa2024.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 1738446
  md5: 7b424ff1637033074cf8241dd9b10c2c

## Thumbnail

fileset_id: 74d2af39-1177-4ead-a2a8-578a997d4600
filename: ThermochimActa2024.docx