# Branched sulfoisobutylbetaine acrylamide polymers with hydrolytically stable amide linkages for long-term durable anti-biofouling surfaces

https://mdr.nims.go.jp/datasets/ef2d181f-29d8-4cb8-bde4-5c619ec2e58b

## File

- [Ver4_PSBBA-HighDurability_ResarchArticle_ENG.pdf](https://mdr.nims.go.jp/filesets/03175fce-4f47-4955-8707-e4a1493d1567/download) ([Detail](https://mdr.nims.go.jp/filesets/03175fce-4f47-4955-8707-e4a1493d1567.md))

## Id

ef2d181f-29d8-4cb8-bde4-5c619ec2e58b

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-02-26T02:21:44.492927Z

## Updated at

2026-02-26T23:30:36.602432Z

## Published at

2026-02-26T08:51:10.321318Z

## Doi

https://doi.org/10.48505/nims.6190

## First published url

https://doi.org/10.1039/D5TB02310F

## Date published

2026-01-26

## Recorded date published

2026-2-18

## Resource type

journal_article

## Manuscript type

authors_original

## Collection



## Title

- title: Branched sulfoisobutylbetaine acrylamide polymers with hydrolytically stable
    amide linkages for long-term durable anti-biofouling surfaces
  title_type: original
  lang: en

## Description

- description: "Functional materials coated with zwitterionic polymers can significantly
    suppress the interactions with biological materials. However, the bio‐inactivity
    of existing zwitterionic polymers lacks long‐term durability, partly owing to
    the cleavage of zwitterionic side chains by the hydrolysis of ester bonds. To
    address this, a novel zwitterionic monomer, \"sulfoisobutylbetaine acrylamide
    (SBBAm)” whose side chain is linked by an amide bond, was synthesized. A copolymer
    with SBBAm and a monomer with a silane‐coupling side chain was synthesized and
    used to modify a glass substrate to analyze the resultant bio‐inactivity and its
    long‐term durability. The performance of the SBBAm copolymer was compared with
    copolymers comprising existing zwitterionic monomers. The results indicated that
    the surface modified with the SBBAm copolymer maintained bio‐inactivity even after
    1 year of incubation in PBS at 37 °C, whereas that of the copolymer with\r\nexisting
    zwitterionic monomers mostly deteriorated after 1 week of incubation. Furthermore,
    the positive effects of the isobutyl linker between the anion and cation units
    in the SBBAm side chain were demonstrated in comparison with the sulfopropylbetaine
    polymer. The molecular design of the SBBAm helps to overcome the water‐insolubility
    of sulfobetainetype polymers, that is, these polymers become water‐insoluble with
    an increase in molecular weight. The results presented here can drive the development
    of a novel zwitterionic polymer material that causes bio‐inactivity with long‐term
    durability."
  description_type: abstract
  lang: und

## Creator

- name: Ryoma Takagi
  role: author
- name: Ayaka Moroto
  role: author
- name: Toshikazu Yamamoto
  role: author
- name: Tadashi Nakaji-Hirabayashi
  role: author
- name: Tatsuya Ishiyama
  role: author
- name: Chiaki Yoshikawa
  role: author
  orcid: https://orcid.org/0000-0002-6589-387X
  organization: National Institute for Materials Science
- name: Hiromi Kitano
  role: author
- name: Shinpei Yamamoto
  role: author
- name: Yoshiyuki Saruwatari
  role: author

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: Zwitterionic polymer
  schema: not_defined
- subject: Acrylamide
  schema: not_defined
- subject: Anti-Biofouling
  schema: not_defined
- subject: Lomg-term stability
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Journal of Materials Chemistry B
  issn: 2050750X
  volume: '14'
  issue: '7'
  start_page: 2257
  end_page: 2269

## Conference



## Related item



## Funding

- identifier: 17KK01130
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: 18K19907
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: 22H03951
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- funder_name: Yamaguchi Scholarship Foundation
- funder_name: National Institute for Materials Science
- identifier: JPMJSP2145
  funder_name: Japan Science and Technology Corporation

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 03175fce-4f47-4955-8707-e4a1493d1567
  filename: Ver4_PSBBA-HighDurability_ResarchArticle_ENG.pdf
  content_type: application/pdf
  size: 1893173
  md5: f2b2f58367dff80ab9e74849ee453c2d

## Thumbnail

fileset_id: 03175fce-4f47-4955-8707-e4a1493d1567
filename: Ver4_PSBBA-HighDurability_ResarchArticle_ENG.pdf