Branched sulfoisobutylbetaine acrylamide polymers with hydrolytically stable amide linkages for long-term durable anti-biofouling surfaces

Ryoma Takagi; Ayaka Moroto; Toshikazu Yamamoto; Tadashi Nakaji-Hirabayashi; Tatsuya Ishiyama; Chiaki Yoshikawa; Hiromi Kitano; Shinpei Yamamoto; Yoshiyuki Saruwatari

doi:10.1039/D5TB02310F

論文 Branched sulfoisobutylbetaine acrylamide polymers with hydrolytically stable amide linkages for long-term durable anti-biofouling surfaces

Ryoma Takagi ; Ayaka Moroto ; Toshikazu Yamamoto ; Tadashi Nakaji-Hirabayashi ; Tatsuya Ishiyama ; Chiaki Yoshikawa (National Institute for Materials Science) ; Hiromi Kitano ; Shinpei Yamamoto ; Yoshiyuki Saruwatari

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Ryoma Takagi, Ayaka Moroto, Toshikazu Yamamoto, Tadashi Nakaji-Hirabayashi, Tatsuya Ishiyama, Chiaki Yoshikawa, Hiromi Kitano, Shinpei Yamamoto, Yoshiyuki Saruwatari. Branched sulfoisobutylbetaine acrylamide polymers with hydrolytically stable amide linkages for long-term durable anti-biofouling surfaces. Journal of Materials Chemistry B. 2026, 14 (7), 2257-2269. https://doi.org/10.1039/D5TB02310F

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(abstract)

Functional materials coated with zwitterionic polymers can significantly suppress the interactions with biological materials. However, the bio‐inactivity of existing zwitterionic polymers lacks long‐term durability, partly owing to the cleavage of zwitterionic side chains by the hydrolysis of ester bonds. To address this, a novel zwitterionic monomer, "sulfoisobutylbetaine acrylamide (SBBAm)” whose side chain is linked by an amide bond, was synthesized. A copolymer with SBBAm and a monomer with a silane‐coupling side chain was synthesized and used to modify a glass substrate to analyze the resultant bio‐inactivity and its long‐term durability. The performance of the SBBAm copolymer was compared with copolymers comprising existing zwitterionic monomers. The results indicated that the surface modified with the SBBAm copolymer maintained bio‐inactivity even after 1 year of incubation in PBS at 37 °C, whereas that of the copolymer with
existing zwitterionic monomers mostly deteriorated after 1 week of incubation. Furthermore, the positive effects of the isobutyl linker between the anion and cation units in the SBBAm side chain were demonstrated in comparison with the sulfopropylbetaine polymer. The molecular design of the SBBAm helps to overcome the water‐insolubility of sulfobetainetype polymers, that is, these polymers become water‐insoluble with an increase in molecular weight. The results presented here can drive the development of a novel zwitterionic polymer material that causes bio‐inactivity with long‐term durability.

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