# Enhanced ROS scavenging and tissue adhesive abilities in injectable hydrogels by protein modification with oligoethyleneimine

https://mdr.nims.go.jp/datasets/ed970860-640a-4cad-a22c-c745fcfa1910

## File

- [59. Biomater. Sci.,2024,12,2312–2320.pdf](https://mdr.nims.go.jp/filesets/a8aa00f5-4ea0-4e0a-9202-13a583a8ffb8/download) ([Detail](https://mdr.nims.go.jp/filesets/a8aa00f5-4ea0-4e0a-9202-13a583a8ffb8.md))

## Id

ed970860-640a-4cad-a22c-c745fcfa1910

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-11T05:58:35.091781Z

## Updated at

2024-08-19T07:30:41.513026Z

## Published at

2024-08-19T07:30:41.581519Z

## Doi



## First published url

https://doi.org/10.1039/d3bm02065g

## Date published

2024-03-13

## Recorded date published

2024-4-30

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Enhanced ROS scavenging and tissue adhesive abilities in injectable hydrogels
    by protein modification with oligoethyleneimine
  title_type: original
  lang: en

## Description

- description: Postsurgical treatment comprehensively benefits from the application
    of tissue-adhesive injectable hydrogels, which reduce postoperative complications
    by promoting wound closure and tissue regeneration. Although various hydrogels
    have been employed as clinical tissue adhesives, many exhibit deficiencies in
    adhesive strength under wet conditions or in immunomodulatory functions. Herein,
    we report the development of reactive oxygen species (ROS) scavenging and tissue-adhesive
    injectable hydrogels composed of polyamine-modified gelatin crosslinked with the
    4-arm poly (ethylene glycol) crosslinker. Polyamine modified gelatin was particularly
    potent in suppressing the secretion of proinflammatory cytokines from stimulated
    primary macrophages. This effect is attributed to its ability to scavenge ROS
    and inhibit the nuclear translocation of nuclear factor kappa-B. Polyamine-modified
    gelatin-based hydrogels exhibited ROS scavenging abilities and enhanced tissue
    adhesive strength on collagen casing. Notably, the hydrogel demonstrated exceptional
    tissue adhesive properties in a wet environment, as evidenced by its performance
    using porcine small intestine tissue. This approach holds significant promise
    for designing immunomodulatory hydrogels with superior tissue adhesion strength
    compared to conventional medical materials, thereby contributing to advancements
    in minimally invasive surgical techniques.
  description_type: abstract
  lang: und

## Creator

- name: Debabrata Palai
  role: author
  orcid: https://orcid.org/0000-0003-1192-6143
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Miho Ohta
  role: author
- name: Iga Cetnar
  role: author
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: Tissue adhesion
  schema: not_defined
- subject: anti-inflammatory
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Biomaterials Science
  issn: '20474830'
  volume: '12'
  issue: '9'
  start_page: 2312
  end_page: 2320

## Conference



## Related item



## Funding

- identifier: 22H03962
  funder_name: Japan Society for the Promotion of Science
- identifier: 23H01718
  funder_name: Japan Society for the Promotion of Science
- funder_name: Uehara Memorial Foundation

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: a8aa00f5-4ea0-4e0a-9202-13a583a8ffb8
  filename: 59. Biomater. Sci.,2024,12,2312–2320.pdf
  content_type: application/pdf
  size: 1484637
  md5: 0e2c1c3060212a0def32a7655d12b345

## Thumbnail

fileset_id: a8aa00f5-4ea0-4e0a-9202-13a583a8ffb8
filename: 59. Biomater. Sci.,2024,12,2312–2320.pdf