# Influence of the Addition of Trace Amounts of Vinylpyrrolidone–Vinyl Acetate Copolymer (PVPVA) on the Crystallization of Celecoxib Glass

https://mdr.nims.go.jp/datasets/e92c78cb-1256-401b-9674-a4712f47465a

## File

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## Id

e92c78cb-1256-401b-9674-a4712f47465a

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-02-19T08:34:17.547466Z

## Updated at

2026-04-30T03:01:11.491392Z

## Published at

2026-08-19T07:24:48.931564Z

## Doi



## First published url

https://doi.org/10.1021/acs.molpharmaceut.5c00934

## Date published

2026-01-05

## Recorded date published

2026-1-5

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Influence of the Addition of Trace Amounts of Vinylpyrrolidone–Vinyl Acetate
    Copolymer (PVPVA) on the Crystallization of Celecoxib Glass
  title_type: original
  lang: en

## Description

- description: Although polymers can prevent the crystallization of glassy drugs in
    amorphous solid dispersions, their stabilization mechanism requires further clarification
    for an efficient formulation design. This study examined the impact of adding
    trace amounts (2 or 5 w/w %) of vinylpyrrolidone−vinyl acetate copolymer (PVPVA)
    on the physical stability of celecoxib (CEL) glass using differential scanning
    calorimetry and broadband dielectric spectroscopy. Long-term isothermal crystallization
    studies from 35 to 60 °C revealed that CEL glass was significantly stabilized
    by the addition of trace amounts of PVPVA. Its stabilization was attributed to
    the effect of PVPVA on the nucleation process rather than on crystal growth. The
    addition of PVPVA slowed down the α-relaxation of CEL, whereas it accelerated
    Johari−Goldstein relaxation. Moreover, the addition of PVPVA effectively slowed
    down γ- and δ-relaxations. Of these, suppression of γ-relaxation mobility had
    the most important effect, as it is related to the formation of hydrogen bonding
    between CEL and PVPVA molecules to inhibit nucleation. Moreover, the change in
    molecular cooperativity of the CEL glass upon adding PVPVA contributed to the
    inhibition of nuclei formation due to the decreased nucleation temperature. This
    study provides detailed insights into the physical stabilization mechanisms of
    glass using polymeric excipients.
  description_type: abstract
  lang: und

## Creator

- name: Xue Han
  role: author
- name: Kaoru Ohyama
  role: author
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: glass
  schema: not_defined
- subject: polymeric excipients
  schema: not_defined
- subject: PVPVA
  schema: not_defined
- subject: crystallization
  schema: not_defined
- subject: broadband dielectric spectroscopy
  schema: not_defined
- subject: differential scanning calorimetry
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Molecular Pharmaceutics
  issn: '15438384'
  volume: '23'
  issue: '1'
  start_page: 280
  end_page: 292

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Fileset

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  filename: 2026MolPharm_CEL_PVPVA.pdf
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  filename: SI_MolPharm.docx
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## Thumbnail

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filename: SI_MolPharm.docx