# Locally Administered Photothermal Therapy for Breast Cancer using Endolysosome-Targeted Indocyanine Green Conjugated with Polycation

https://mdr.nims.go.jp/datasets/e8a59a4e-acdd-473e-a072-6046b0562a65

## File

- [locally-administered-photothermal-therapy-for-breast-cancer (2).pdf](https://mdr.nims.go.jp/filesets/d6257d45-4d5a-48c4-9f5d-9803d09be853/download) ([Detail](https://mdr.nims.go.jp/filesets/d6257d45-4d5a-48c4-9f5d-9803d09be853.md))

## Id

e8a59a4e-acdd-473e-a072-6046b0562a65

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-11-24T05:21:17.475664Z

## Updated at

2024-11-25T07:30:43.936109Z

## Published at

2024-11-25T07:30:44.233453Z

## Doi



## First published url

https://doi.org/10.26502/jsr.10020350

## Date published

2024-03-28

## Recorded date published

2024

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Locally Administered Photothermal Therapy for Breast Cancer using Endolysosome-Targeted
    Indocyanine Green Conjugated with Polycation
  title_type: original
  lang: en

## Description

- description: Near-infrared photothermal therapy using indocyanine green has a great
    potential of anti-tumor therapy against deep tumor tissue owing to its biological
    transparency window and high spatiotemporal selectivity. However, even intratumor
    administration of indocyanine green does not show high antitumor efficacy. To
    improve the anti-tumor efficacy of indocyanine green, in this study, we have developed
    a locally administered photothermal therapy using indocyanine green with polycations
    bearing quaternary ammonium salt groups, referred to as aICG. The aICG was accumulated
    in endolysosome via endocytosis after cell adhesion by electrostatic interaction,
    and induced apoptosis by laser irradiation at 808 nm, while low-molecular-weight
    ICG distributed in the cytoplasm. Photothermal therapy with intratumor injection
    of aICG showed a higher anti-tumor effect upon the light irradiation at 808 nm,
    compared to low-molecular-weight ICG. In addition, the treatment with aICG did
    not cause any adverse effects such as weight loss, and hepatic and renal dysfunctions.
    Therefore, aICG has a potential as photothermal agent for locally administered
    photothermal therapy.
  description_type: abstract
  lang: und

## Creator

- name: Saori Fujiwara
  role: author
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
  organization: National Institute for Materials Science
- name: Aoi Hoshi
  role: author
- name: Van Thi Hong Doan
  role: author
  orcid: https://orcid.org/0000-0002-0208-2834
  organization: National Institute for Materials Science
- name: Yoshiki Komatsu
  role: author
- name: Huajian Chen
  role: author
  organization: National Institute for Materials Science
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
  organization: National Institute for Materials Science
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678
  organization: National Institute for Materials Science
- name: Azusa Terasaki
  role: author
- name: Hiroko Bando
  role: author
- name: Hisato Hara
  role: author
- name: Hirofumi Matsui
  role: author

## Contact agent



## Publisher

organization: Fortune Journals

## Managing organization



## Keyword

- subject: Endolysosome
  schema: not_defined
- subject: Polycation
  schema: not_defined
- subject: Indocyanine green
  schema: not_defined
- subject: Photothermal therapy
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Journal of Surgery and Research
  issn: '26401002'
  volume: '7'
  issue: '1'
  start_page: 122
  end_page: 133

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: d6257d45-4d5a-48c4-9f5d-9803d09be853
  filename: locally-administered-photothermal-therapy-for-breast-cancer (2).pdf
  content_type: application/pdf
  size: 1928155
  md5: 866e7e856555563dd2247275153a785c

## Thumbnail

fileset_id: d6257d45-4d5a-48c4-9f5d-9803d09be853
filename: locally-administered-photothermal-therapy-for-breast-cancer (2).pdf