# Bioinspired Hyperboloid Mechanical Metamaterial for Shock Absorption and Strain Regulation in Cartilage Remodeling https://mdr.nims.go.jp/datasets/e7ab578c-dba0-435a-8f1e-3581e82c41f1 ## Files - [AM.pdf](https://mdr.nims.go.jp/filesets/50d32d49-a497-4cc9-8465-a2848eebd62f/download) ([Detail](https://mdr.nims.go.jp/filesets/50d32d49-a497-4cc9-8465-a2848eebd62f.md)) ## Id e7ab578c-dba0-435a-8f1e-3581e82c41f1 ## Local identifier ## Visibility open_to_public ## State published ## Created at 2025-10-23T07:45:22.799560Z ## Updated at 2025-12-04T01:50:07.355426Z ## Published at 2026-06-30T23:29:59.601800Z ## Doi https://doi.org/10.48505/nims.5957 ## First published url https://doi.org/10.1002/adma.202503183 ## Date published 2025-07-01 ## Recorded date published 2025-9 ## Resource type journal_article ## Manuscript type accepted_manuscript ## Collection ## Title - title: Bioinspired Hyperboloid Mechanical Metamaterial for Shock Absorption and Strain Regulation in Cartilage Remodeling title_type: original lang: en ## Description - description: Inspired by the shock-absorbing capabilities of natural insect elytra, a hyperboloid lattice metamaterial exhibiting unique compression-torsion coupling behavior is designed and fabricated. This structure efficiently converts dynamic loads into strain energy, enabling high-strain elastic deformation. The hyperboloid lattice is integrated with a classic reticulation framework and filled with GelMA hydrogel, creating a tailored osteochondral scaffold with mechanical properties that closely match those of joint tissue. Under dynamic mechanical culture, compression-torsion stimulation in the hyperboloid zone induced high-strain elastic deformation, promoting chondrogenic differentiation of stem cells, while the more rigid reticulation zone, experiencing minimal deformation, facilitated osteogenic differentiation of stem cells. In a rabbit osteochondral defect model, hyperboloid-based shock-absorption scaffolds significantly enhanced the integrative repair of both cartilage and subchondral bone via the NF-κB and calcium signaling pathways. The incorporation of the hyperboloid metamaterial, with its shock-absorbing and strain-regulating properties, demonstrates great potential for developing adaptable mechanical scaffolds for cartilage remodeling. description_type: abstract lang: und ## Creator - name: Jia Chen role: author orcid: https://orcid.org/0000-0001-8675-6930 - name: Qingqing Sun role: author orcid: https://orcid.org/0000-0002-6019-9272 - name: Yuliang Hou role: author orcid: https://orcid.org/0000-0003-0370-1251 - name: Shuaibing Liu role: author - name: Litao Wang role: author - name: Eshuang Deng role: author - name: Liang Meng role: author orcid: https://orcid.org/0000-0001-7261-5918 - name: Xiaomeng Li role: author orcid: https://orcid.org/0000-0002-8143-1122 - name: Guoping Chen role: author orcid: https://orcid.org/0000-0001-6753-3678 - name: Jianglin Wang role: author orcid: https://orcid.org/0000-0002-0733-2097 ## Contact agent ## Publisher organization: Wiley ## Managing organization ## Keyword - subject: GelMA hydrogel schema: not_defined - subject: osteochondral scaffold schema: not_defined - subject: tissue engineering schema: not_defined ## Rights - description: 'This is the peer reviewed version of the following article: J. Chen, Q. Sun, Y. Hou, et al. “ Bioinspired Hyperboloid Mechanical Metamaterial for Shock Absorption and Strain Regulation in Cartilage Remodeling.” Adv. Mater. 37, no. 37 (2025): 37, 2503183, which has been published in final form at https://doi.org/10.1002/adma.202503183. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.' identifier: http://rightsstatements.org/vocab/InC/1.0/ ## Other identifier(s) ## Data origin - data_origin_type: other ## Embargo start_date: 2025-07-01 end_date: 2026-07-01 ## Journal - title: Advanced Materials issn: '09359648' volume: '37' issue: '37' article_number: '2503183' ## Conference ## Related item ## Funding - identifier: '32171323' funder_name: National Natural Science Foundation of China - identifier: 2022YFA1105100 funder_name: National Key Research and Development Program of China - identifier: 2024JYCXJJ024 funder_name: Fundamental Research Funds for the Central Universities - identifier: JCYJ20241202125205007 funder_name: Shenzhen Science and Technology Innovation Program - identifier: KCXFZ20211020164544008 funder_name: Science, Technology and Innovation Commission of Shenzhen Municipality ## Instrument ## Instrument operator ## Instrument managing organization ## Measurement method ## Specimen ## Chemical composition ## Structure for specimen ## Structural feature for specimen ## Specific property for specimen ## Process for specimen treatment ## Computational method ## Energy level/transition state ## Software ## Custom property ## Fileset - id: 50d32d49-a497-4cc9-8465-a2848eebd62f filename: AM.pdf content_type: application/pdf size: 4825582 md5: 7969e260963c23d90bf4d7bb3f55510e ## Thumbnail fileset_id: 50d32d49-a497-4cc9-8465-a2848eebd62f filename: AM.pdf