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Inspired by the shock-absorbing capabilities of natural insect elytra, a hyperboloid lattice metamaterial exhibiting unique compression-torsion coupling behavior is designed and fabricated. This structure efficiently converts dynamic loads into strain energy, enabling high-strain elastic deformation. The hyperboloid lattice is integrated with a classic reticulation framework and filled with GelMA hydrogel, creating a tailored osteochondral scaffold with mechanical properties that closely match those of joint tissue. Under dynamic mechanical culture, compression-torsion stimulation in the hyperboloid zone induced high-strain elastic deformation, promoting chondrogenic differentiation of stem cells, while the more rigid reticulation zone, experiencing minimal deformation, facilitated osteogenic differentiation of stem cells. In a rabbit osteochondral defect model, hyperboloid-based shock-absorption scaffolds significantly enhanced the integrative repair of both cartilage and subchondral bone via the NF-κB and calcium signaling pathways. The incorporation of the hyperboloid metamaterial, with its shock-absorbing and strain-regulating properties, demonstrates great potential for developing adaptable mechanical scaffolds for cartilage remodeling.

権利情報:

• In Copyright
  

  This is the peer reviewed version of the following article: J. Chen, Q. Sun, Y. Hou, et al. “ Bioinspired Hyperboloid Mechanical Metamaterial for Shock Absorption and Strain Regulation in Cartilage Remodeling.” Adv. Mater. 37, no. 37 (2025): 37, 2503183, which has been published in final form at https://doi.org/10.1002/adma.202503183. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

キーワード: GelMA hydrogel, osteochondral scaffold, tissue engineering

刊行年月日: 2025-07-01

出版者: Wiley

掲載誌:

• Advanced Materials (ISSN: 09359648) vol. 37 issue. 37 2503183

研究助成金:

• National Natural Science Foundation of China 32171323
• National Key Research and Development Program of China 2022YFA1105100
• Fundamental Research Funds for the Central Universities 2024JYCXJJ024
• Shenzhen Science and Technology Innovation Program JCYJ20241202125205007
• Science, Technology and Innovation Commission of Shenzhen Municipality KCXFZ20211020164544008

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5957

公開URL: https://doi.org/10.1002/adma.202503183

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更新時刻: 2025-12-04 10:50:07 +0900

MDRでの公開時刻: 2026-07-01 08:29:59 +0900