# Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles

https://mdr.nims.go.jp/datasets/e742c093-1dd2-4473-bd99-4759df4ba4a3

## File

- [SiO2NPs_Ichihara_PFT26.pdf](https://mdr.nims.go.jp/filesets/7230019d-8cf0-4b13-b7f2-07d0781aa7b9/download) ([Detail](https://mdr.nims.go.jp/filesets/7230019d-8cf0-4b13-b7f2-07d0781aa7b9.md))

## Id

e742c093-1dd2-4473-bd99-4759df4ba4a3

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-03-06T02:00:48.664894Z

## Updated at

2026-03-07T03:30:12.328731Z

## Published at

2026-03-07T00:46:06.605914Z

## Doi



## First published url

https://doi.org/10.1186/s12989-025-00653-6

## Date published

2025-12-19

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Impact of surface functional group modification on cellular internalization
    and cytotoxicity of silica nanoparticles
  title_type: original
  lang: en

## Description

- description: "Silica nanoparticles (SiO2NPs) are widely used in industrial products.
    Surface modification of SiO2NPs is one of the promising strategies to develop
    safer nanomaterials by design. The present study was designed to determine the
    effects of amino or carboxyl functionalization of rhodamine-labeled SiO2NPs on
    cellular uptake \r\nand cytotoxicity. \r\n NH2- or COOH-functionalization reduced
    the harmful changes observed with OH- SiO2NPs, which included increase in lung
    weight and BALF neutrophils at low dose in mice as well as decrease in cell viability
    and upregulation of proinflammatory cytokines in RAW264.7 macrophages. The results
    suggested that OH-SiO2NPs-induced cytotoxicity against macrophages was mediated
    at least in part through apoptotic/necroptotic signaling but was not related to
    internalization of particles. The results imply possible development of safer
    silica nanoparticles by amino- or carboxyl-functionalization of their silanols.
    \ "
  description_type: abstract
  lang: und

## Creator

- name: Sandra Vranic
  role: author
- name: Eri Watanabe
  role: author
- name: Kyoka Yamazaki
  role: author
- name: Takatsugu Wakahara
  role: author
  orcid: https://orcid.org/0000-0002-6365-3215
- name: Kayoko Miyakawa
  role: author
- name: Sakie Takeuchi
  role: author
- name: Yurika Osada
  role: author
- name: Sahoko Ichihara
  role: author
- name: Wenting Wu
  role: author
- name: Cai Zong
  role: author
- name: Toshihiro Sakurai
  role: author
- name: Akira Sato
  role: author
- name: Yasushi Hara
  role: author
- name: Akihiko Ikegami
  role: author
- name: Yuya Terashima
  role: author
- name: Kouji Matsushima
  role: author
- name: Toshihiro Suzuki
  role: author
- name: Ryo Abe
  role: author
- name: Sonja Boland
  role: author
- name: Lang Tran
  role: author
- name: Gaku Ichihara
  role: author

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: Silica Nanoparticles
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Particle and Fibre Toxicology
  issn: '17438977'
  volume: '23'
  issue: '1'
  article_number: '9'

## Conference



## Related item



## Funding

- identifier: LS056
  funder_name: JSPS
- identifier: "#PE13040"
  funder_name: Japan Society for the Promotion of Science
- funder_name: Japan Science and Technology Agency

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 7230019d-8cf0-4b13-b7f2-07d0781aa7b9
  filename: SiO2NPs_Ichihara_PFT26.pdf
  content_type: application/pdf
  size: 4903295
  md5: 415879e90168beed0b6f8701c1b5d191

## Thumbnail

fileset_id: 7230019d-8cf0-4b13-b7f2-07d0781aa7b9
filename: SiO2NPs_Ichihara_PFT26.pdf